Heartbreak

3. detailing myocardial _____ in MDD can inform approaches to cardioprotection but this is currently ill defined
6. decreased ____ tone has been implicated in psychocardiac coupling
11. PINE network is an abbreviation for what (no spaces or dashes)
13. major neurotransmitter in MDD and peripherally acts as a mediator of inflammation

1. MDD increases the risk of recurrent cardiac events and death ___-fold.
2. overactivity of this part of the nervous system has been implicated in psycho-cardiac coupling
4. this axis, along with immuno-inflammatory dysfunction has been implicated in psychocardiac coupling
5. myocyte contractile properties are impaired due to lack of this element in depression or chronic stress
7. in addition to systemic factors, this structure is directly modified in depression
8. receptor type implicated in vagally mediated cardiac protection
9. percentage of patients referred for cardiac catheterization and angiography with pre-existing MDD
10. induction of Bax and Bcl-xl transcripts in a rodent model of depression predisposes cardiac tissue to undergo _____
12. this very important protein complex is heavily used in innate cells of the immune system and has been implicated in schizophrenia, cardiac disease, and addictive disorders in addition to cancer and immune conditions. (abbreviation, no dashes or spaces)