Heather Augustine ALE 2.10.16

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Across
  1. 4. Used for melanoma and can cause vitiligo, and herpes infections
  2. 5. a proteasome inhibitor that should be monitored for vision changes and is an irreversible inhibitor of 20S proteasome
  3. 7. A hedgehog pathway inhibitor that causes rhabdo, dysgeusia, hyperglycemia and must use a condom for up to 8 months after completion of medication
  4. 8. A histone deactylase inhibitor that causes taste abnormalities, hyperglycemia,l and edema
  5. 10. Used for CD25 T-cell lymphoma that can cause capillary leak syndrome and vision changes (brand name)
  6. 13. A tyrosine kinase that needs to be reduced in renal impairment by 50%
  7. 14. A histone deactylase inhibitor that causes severe thrombocytopenia, severe diarrhea, and severe infections
  8. 16. A proteasome inhibitor that can cause conjunctivitis, SJS, severe thrombocytopenia and is a substrate of CYP3A4
  9. 17. A VEGF inhibitor with a BBW for GI perforation, hemorrhage, and impaired wound healing (brand name)
  10. 20. Oral medication that inhibits Pl3K-delta that has a BBW for bowel perforation, severe diarrhea, and hepatotoxicity
  11. 21. A monoclonal antibody that has delayed wound healing (hold 28 days before and restart 28 days after surgery)
  12. 22. a tyrosine kinase that elevates INR and causes bleeds if given with Warfarin
  13. 23. A monoclonal antibody that requires to monitor vital signs for up to 1 hour after infusion and the KRAS mutation makes it ineffective
Down
  1. 1. A monoclonal antibody with the side effect of PML from JC virus
  2. 2. A tyrosine kinase that is taken orally with Capecitabine
  3. 3. A mTOR inhibitor that is taken orally and has wound healing complications
  4. 4. A mTOR inhibitor that is contraindicated in bilirubin >1.5x ULN
  5. 6. A tyrosine kinase that targets Ph+ chromosome and causes QT prolongation
  6. 9. A histone deactylase inhibitor that can cause hepatotoxicity and infection
  7. 11. A monoclonal antibody that requires a pregnancy test before taking
  8. 12. Oral medication that can cause nose bleeds, peripheral neuropathy and thrombocytopenia
  9. 15. A proteasome inhibitor that blocks activity at 26S proteasome and should be used with caution with strong inhibitors
  10. 18. A hedgehog pathway inhibitor that causes alopecia, dysgeusia and must use a condom for up to 7 months after completion of medication
  11. 19. An oral medication that is a PARP inhibitor that can cause bone pain, back pain, and secondary malignancies