Across
- 3. also known as brittle bone disease.
- 6. inactives protein that promotes blood clots and acts with protein c.
- 12. increased levels of uremic toxins such as guanidosuccinic acid and phenols.
- 15. the removal, return, or exchange of blood plasma or components.
- 16. illness that develops at some point during its life.
- 18. phenomenon that occurs to platelets iin Kasabach-Merritt Syndrome.
- 20. plaque in the artery causing blockage that may lead to Myocardial infarction.
- 22. enzyme-linked immunoabsorbent assay.
- 23. Factor VII.
- 27. characterized by an increase in the circulating platelet counts greater than 450,000/uL.
- 28. a specific von Willebrand factor-cleaving metalloprotease found in plasma.
- 30. breaking down of elastic fibers.
- 32. serine protease inhibitor (serpin) that neutralizes thrombin, Factor Ixa, Xa, Xia & XIIa.
- 36. type of VWD that is an autosomal recessive or severe type.
- 38. other name of purpura simplex.
- 41. most frequently used coumarin which is water soluble and administered orally.
- 45. the treatment of choice for ITP.
- 46. a protein responsible for stabilizing the platelet plug.
- 47. it is a syndrome related to preeclampsia/eclampsia, defined by elevated liver enzymes, and low platelet count.
- 49. a sudden or quick emergence of a condition.
- 52. commonly used to decrease the period of thrombocytopenia in ITP.
- 54. nose bleeding.
- 55. removal of a body part such as finger, toe, hand, foot, or leg.
- 57. this is the one that is absent in a platelet disorder, with a mutation in the RBM8A in chromosome 1.
- 59. enlargement of the spleen.
- 61. most common infectious agent causing neonatal thrombocytopenia.
- 62. jew people with hemophilia C.
- 63. a platelet disorder with mutation in the (blank).
- 65. spontaneous remissions with or without therapy like Idiophatic Thrombocytopenic Purpura.
- 67. a surgical procedure to remove the spleen.
- 68. a prolonged period of menstruation in adult ITP.
- 70. an anomaly characterized by macrothrombocytopenia with dohle-like bodies.
- 72. excessive amount of protein, associated with multiple myeloma and waldenstrom macroglobulinemia.
- 73. a bleeding disorder characterized by problem with GPIIB-IIIA
- 74. a condition in which the tissue lining of the heart becomes inflamed caused by bacteria.
- 76. a zymogen that is cleaved to form plasmin.
- 77. soluble protein that is broken down to fibrin.
- 78. small red spot that appears on the skin.
Down
- 1. inherited from parents to their offspring.
- 2. overreactive function of spleen, increasing the destruction of platelets.
- 4. deficiency resulting from a lack of vitamin C.
- 5. an autosomal-dominant genetic syndrome due to mutation of the gene for fibrillin resulting in abnormalities of connective tissues and risk for bleeding and bruising.
- 7. a syndrome known as X-linked hereditary with mutation in GTA 1 gene.
- 8. this is a factor VIII:C deficiency, also known as royal disease.
- 9. total lack of fibrinogen.
- 10. treatment for afibrinogenemia.
- 11. a severe form of bleeding that requires immediate intervention and transfusion.
- 13. coughing up blood.
- 14. clinical manifestation of red blood cell extravasation into mucosa or skin
- 17. it attacks platelets of the fetal, seen in neonatal alloimmune thrombocytopenia (NAIT).
- 19. defined by the occurrence of acute neurologic abnormalities in a preeclamptic woman during peripartum period.
- 20. immediate systemic reactions that mimic anaphylaxis but are not caused by IgE-mediated immune responses.
- 21. intravenous anticoagulant most commonly used in clinical medicine.
- 24. cofactor of thrombin that inhibits procoagulant function.
- 25. a syndrome characterized with macrothrombocytopenia without dohle-like bodies.
- 26. long time or persistent clinical condition.
- 28. spontaneous bleeding caused by deposition of amyloid protein around small vessels.
- 29. purple-bluish bruise caused by broken blood vessels.
- 31. refers to an increased tendency to develop thrombi or emboli.
- 33. sudden appearance of symptoms, change, or worsen rapidly.
- 34. dysfunctional fibrinogen.
- 35. most frequent causes of drug-induced thrombocytopenia where it acts as a hapten.
- 37. a therapy for HIV patients.
- 39. deficiency in fibrinogen.
- 40. serious condition in which the body responds improperly to an infection.
- 42. defined by hypertension and proteinuria; usually becomes evident during the second trimester and is a major contributor to maternal and fetal morbidity and mortality.
- 43. a machine filters the wastes, salts, and fluids from the blood when kidneys no longer function.
- 44. significant decrease in all blood cells.
- 48. bleeding in joints.
- 50. production of cryoprecipitable serum proteins or protein complexes.
- 51. regulatory protein.
- 53. the name of purpura commonly seen in children that is typically reversible.
- 56. surface activator used in APTT
- 58. fragmented RBC that is also known as helmet cells.
- 60. a serine protease responsible for fibrin degradation during fibrinolysis.
- 64. swelling of legs or arms caused by build-up of fluid in the tissue.
- 66. anything that moves through blood vessels until it gets stuck in a vessel that’s too small to pass through.
- 69. reduction in the number or quantity.
- 71. type of tissue death caused by a lack of blood supply.
- 75. a pharmacological agent, 1-desamino-8-D-arginine-vasopressin.