Hemaglobinopathies

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Across
  1. 2. : Low oxygen state that promotes sickling
  2. 3. : Inherited disorder with defective hemoglobin synthesis
  3. 6. : Tetramer protein responsible for oxygen transport in blood
  4. 8. : Decreased protein in hemolysis
  5. 10. : RBC size classification seen in thalassemia (low MCV)
  6. 11. : Condition that reduces oxygen binding and promotes sickling
  7. 16. : Destruction of RBCs seen in sickle cell disease
  8. 19. crisis : Pain crisis due to ischemia and infarction
  9. 21. : Trigger that worsens sickle cell crises
  10. 22. : RBCs with decreased hemoglobin concentration (low MCHC)
  11. 24. F : Predominant hemoglobin in infants (<2% in adults)
  12. 25. : Lab test used to detect different hemoglobin types
Down
  1. 1. cells : RBC morphology seen in thalassemia
  2. 2. : Iron overload disorder causing tissue damage
  3. 4. Variation in RBC size and shape
  4. 5. anemia : Severe form of beta thalassemia (major)
  5. 7. : Elevated lab value due to RBC breakdown
  6. 9. chest syndrome : Leading cause of death in sickle cell disease
  7. 12. : Surgical treatment option in hemoglobinopathies
  8. 13. : Treatment used in secondary iron overload
  9. 14. chain : Globin chain present in fetal hemoglobin
  10. 15. chain : Globin chain mutated in sickle cell disease
  11. 17. : Increased immature RBCs in hemolysis
  12. 18. : Treatment for primary hemochromatosis
  13. 20. cell disease : Autosomal recessive disorder with Hgb S
  14. 23. : Medication that increases fetal hemoglobin
  15. 24. A : Adult hemoglobin composed of 2 alpha + 2 beta chains