Hematology/Oncology

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Across
  1. 1. drug class MOA: inhibit microtubule disassembly
  2. 5. immunotherapy CTL4 receptor
  3. 7. pap tests = for ___ cancer
  4. 11. ___ analogs MOA: Capecitabine, Fluorouracil - inhibit thymidylate synthetase and pyrimidine synthesis;
  5. 13. ____ antimetabolites MOA: prevents DNA synthesis of purines
  6. 15. immunotherapy HER-2/neu
  7. 17. PSA is the historical test for ___ cancer
  8. 19. ___ ___ genes: mutations inactivating these genes lead to increased growth
  9. 21. fecal occult blood testing = test for ___ cancer
  10. 22. drug class MOA: prevent microtubule assembly (one word)
  11. 23. low-dose computed tomography (LDCT) for those who have a history of smoking = test for ___ cancer
  12. 25. Cancer cells stimulate local ___
  13. 26. test for ___ cancer = telling doctor when having weird looking spot on your skin
  14. 27. immunotherapy VEGF-A
  15. 29. Aromatase inhibitors inhibit aromatase which is necessary for the synthesis of ___ and estradiol
  16. 30. immunotherapy EGFR
  17. 31. Cancer cells proliferate ___
  18. 33. Cancer cells are insensitive to ___ signals
  19. 35. Topoisomerase II inhibitors: inhibit topoisomerase II and block ___ DNA
  20. 36. signs/symptoms of ___ are unexplained weight loss of >10 lbs or more, fever, fatigue, pain, skin changes
  21. 38. immunotherapy CD-20
Down
  1. 2. Cytarabine, Gemcitabine MOA: inhibit DNA chain ___
  2. 3. no evidence screening test improve mortality in ___ cancer
  3. 4. drug class MOA: inhibit tyrosine kinases which are often involved with cellular growth and differentiation
  4. 6. drug class MOA: cross-linked DNA preventing cell replication
  5. 8. Cancer cells are self-sufficient in growth ___
  6. 9. mammography & awareness teaching = test for ___ cancer
  7. 10. used after diagnosis to track progress of therapy (two words)
  8. 11. normal genes that when mutated, turn into oncogenes which promote cellular growth
  9. 12. drug class MOA: intercalation of DNA, inhibit topoisomerase II, generate free radicals
  10. 14. Proteasome inhibitors inhibit proteasome in cancer cells which are necessary for cell cycle ___
  11. 16. angiogenesis --> blood vessels that ___ cancer cells
  12. 18. Cancer cells invade local ___ and spread to other parts of the body
  13. 20. drug class MOA: cross-links DNA resulting in apoptosis (one word)
  14. 24. topoisomerase 1 inhibitors: inhibit top 1 which prevents DNA ____
  15. 28. Cancer cells display loss of contact ___ in vitro
  16. 32. Cancer cells evade ___
  17. 34. drug class MOA: estrogen antagonists in some tissue (breast), and agonists in bone (less osteoporosis than aromatase inhibitors)
  18. 37. Cancer cells display diminished ___ control