Hematopoietic Module – Week 2

3. Protein that exports iron from enterocytes into the bloodstream.
6. Destruction of red blood cells.
10. Effect describing reduced oxygen affinity in the presence of increased CO2 and H+.
12. Drug that increases fetal hemoglobin production.
14. Another name for vitamin B12.
15. Form of hemoglobin containing ferric iron.
16. Primary site of erythropoiesis in adults.
17. Immature red blood cell released from bone marrow.
19. Liver hormone that decreases iron absorption by degrading ferroportin.
20. Molecule transported by hemoglobin.
21. Glycoprotein required for vitamin B12 absorption.
24. Hemoglobin with the highest oxygen affinity.
26. Oxygen-binding protein found in skeletal muscle.
27. Amino acid replaced in sickle cell disease.
30. Oxygen-carrying protein in red blood cells.

1. Primary site of dietary iron absorption.
2. Oxidation state of iron that binds oxygen in hemoglobin.
4. Hormone that stimulates red blood cell production.
5. Vitamin deficiency causes megaloblastic anemia without neurological symptoms.
7. Site of vitamin B12 absorption.
8. Plasma protein that transports iron in the blood.
9. Direction of oxygen dissociation curve shift with alkalosis and fetal hemoglobin.
11. Shape change of HbS-containing red blood cells in low oxygen.
13. Iron-containing prosthetic group of hemoglobin.
18. Pigment produced from heme degradation.
22. Direction of oxygen dissociation curve shift with exercise and acidosis.
23. Property by which binding of one oxygen increases affinity for the next.
25. Transporter responsible for iron uptake into enterocytes.
28. Amino acid that replaces glutamic acid in sickle cell disease.
29. Iron storage protein inside cells.