Heme Things

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Across
  1. 3. A treatment that can lower circulating bilirubin levels in jaundiced babies
  2. 4. The first step in heme biosynthesis is the condensation of (this amino acid) and succinylcoA to form δ-aminolevulinic acid (ALA)
  3. 6. _____ is formed in the intestine when glucoronic acid is removed from bilirubin
  4. 9. This kind of jaundice is associated with elevated AST and ALT levels, along with liver damage
  5. 10. RBCs become ____ (think: they become smaller) due to lack of hemoglobin
  6. 14. _____ bilirubin is transported through the blood to the liver
  7. 21. ALA synthase is found in this organelle
  8. 22. ____ phosphate (aka vitamin B6) is used as a cofactor in by ALA synthase
  9. 24. _______ bilirubin is secreted into bile and then the intestine
  10. 25. ALA ____ is a Zn enzyme that catalyzes the condensation of 2 ALA molecules
Down
  1. 1. This product is formed from the second step of heme biosynthesis in the cytoplasm, with the condensation of 2 ALA molecules
  2. 2. A jaundiced patient with an acute drop in hematocrit would most likely have this type of jaundice
  3. 5. Heme gets broken down into _____ in macrophages of the reticula-endothelial system
  4. 7. Jaundiced newborns have a deficiency or underactive bilirubin ______-transferase enzyme
  5. 8. ____ poisoning displaces the Zn portion of ALA dehydratase, rendering it nonfunctional
  6. 11. Porphyria ____ tarda is the most common porphyria. It results in uroporphyrin accumulation in urine and photosensitivity
  7. 12. To keep the TCA cycle going during upregulation of heme synthesis, pyruvate ______ diverts some pyruvate to be used for oxaloacetate synthesis
  8. 13. The two kinds of porphyrias are erythroid and _____
  9. 15. The first reaction of heme biosynthesis releases CO2 and ____
  10. 16. A jaundiced patient with a large mass in his pancreas may have this type of jaundice
  11. 17. The reaction catalyzed by ALA synthase to make ALA is inhibited by ____ (Fe2+) and hemin (Fe3+)
  12. 18. Hypochromic, microcytic anemia can result from lack of ____ (a metal), defects in heme synthesis, or defects in hemoglobin protein production (thalassemia)
  13. 19. During UPregulation of heme synthesis in this organ, the TCA cycle intermediate succinylcoA is depleted
  14. 20. Nonfunctional ALA dehydratase results in increased ALA levels and _____
  15. 23. In ____ Intermittent Porphyria, porphobilinogen and ALA accumulate in the urine, which darkens on exposure to light and air