Across
- 2. A child developed a rash and abdominal pain following a short bout of the common cold. When taken to the doctor, they found the child had proteinuria and hematuria. What is the most likely diagnosis?
- 5. A patient was admitted to the ED with a blood clot in their leg and was promptly put on an anti-coagulant called Heparin. The next day their platelet count had rapidly dropped to 105 x 103/ mm3. When doing further lab work, it was found that the patient had developed an antibody to platelet factor 4 - heparin complex. What causes this?
- 6. Type of anti-coagulant that is commonly used in hemostasis and binds calcium. Requires a full tube of blood as the 1:10 ratio is critical
- 7. A 63 year old woman goes in for routine bloodwork, but the analyzer flagged her results, one of which being a platelet count of 750 x 103/ mm3, requiring a manual differential. When the tech made a new peripheral smear and looked at it, they noticed normal RBC and WBC counts and morphology, but large masses of platelet aggregation, many giant platelets with bizarre morphology. What is the most likely diagnosis
- 10. Circulating protease that breaks large VWF multimers into smaller forms when functioning correctly
- 11. A pregnant woman comes in for her 38 week check up, at intake her blood pressure is elevated, and she reports fatigue and nausea. She is sent to the ED where they draw labs. Her labwork comes back as follows: Proteinuria, hematuria, Elevated AST, ALT, and LDH, a low platelet count, and a manual blood smear revealed schistocytes - What should doctors be concerned about?
- 13. This is the reference method for aggregation measurement, uses PPP as a blank, adds an aggregating agent to PRP
- 15. Autoimmune Thrombocytopenia - A mother admits to the OBGYN in labor and has a history of systemic lupus erythematosus. What should doctors be concerned about the fetus developing?
- 16. A hereditary vascular disorder that also affects collagen. People with this disorder tend to be hypermobile and have soft/stretchy skin.
- 18. A type of storage pool disease that results in decrease of both alpha and dense granules in platelets, low platelet counts and morphology, and a decrease in serum IgM
Down
- 1. A 10 year old child had the flu for a couple days and then recovered with no issue. Two weeks later, his mother noticed he had started bruising easier and was bleeding more than usual. She took him to the doctor and his test results are as follows: Low platelet count with many large platelets, An increased bleeding time, and had deficient clot retraction. What should the doctor consider for diagnosis?
- 3. A young child comes into the ED, their lab results consist of schistocytes, low platelets, hematuria, protein in the urine, and several types of casts including RBC and RTE casts - what is their most likely diagnosis?
- 4. A patient presents to their doctor with easy bruising and bleeding. They report that a few other family members are also “bleeders”. The lab work shows normal platelet count and morphology, a normal APTT, increased PFA, and abnormal platelet aggregation that was normal only w/ Ristocetin. Which disorder typically presents with these findings?
- 8. An obsolete test that can evaluate platelet function and number only, can not evaluate coagulation cascade. Involves making a shallow cut to the skin and timing until a clot forms
- 9. A test that can be used as screening for Dengue Fever, although a negative result does not rule it out, and a positive result is not diagnostic. Usually involves checking for petechiae both before and after testing
- 12. A disorder of release reaction that causes a decrease in alpha and/or dense granules in platelets and causes abnormal aggregation
- 14. This disorder usually presents with these lab findings: Increase PFA, Low platelet count but large platelet morphology, and normal platelet aggregation with all agents but ristocetin
- 17. Type of anti-coagulant that chelates calcium and is most commonly used in hematology and molecular testing