IMMU3202 Week 3 revision

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Across
  1. 4. Progressive loss of T cell effector function due to prolonged antigen stimulation, characteristic of chronic infections and cancer is known as what?
  2. 6. Pembrolizumab is a famous cancer immunotherapy which blocks what T cell surface protein? Hint: checkpoint blockade
  3. 7. To undergo Antibody Dependent Cellular Cytotoxicity, what receptor do NK cells bind to?
  4. 8. A receptor that allows leukocytes to pass through the epithelium to the site of infection
  5. 11. Tuberculosis is what type of bacterial infection?
  6. 14. What transcription factor is the master regulator in development and function of T regulatory cells?
  7. 15. A process by which TFH cell-activated B cells produce antibodies with increased affinity for antigen during the course of an immune response
  8. 18. Before getting a donor transplant you have to undergo what type of matching?
  9. 20. A disease where an individual is deficient in T and B lymphocytes
  10. 21. this cytokine upregulates MHC-II
  11. 22. HIV requires the CD4 receptor and what other receptor to infect CD4 T cells?
  12. 23. Forgein antigen must bind to which molecule to activate T cells
Down
  1. 1. Alpha and beta chain are components of what lymphocyte receptor?
  2. 2. Some phagocytosed organisms can prevent the fusion of the phagosome with what organelle as a form of immune evasion?
  3. 3. The process by which APCs present on MHC-I instead of MHC-II is known as what?
  4. 5. What type of study investigates the risk of disease associated with variation in SNPs across the whole genome (acronym)
  5. 9. If an immature T cell strongly binds to its antigen it undergoes what form of selection?
  6. 10. Which cytokine is produced early after antigen recognition and promotes growth and survival of T cells?
  7. 12. What subset of memory T cells homes to lymph nodes and have limited effector function?
  8. 13. antibodies are most effective at what stage of the viral lifecycle?
  9. 15. TI interferons produced by infected cells induce what type of state in neighbouring cells?
  10. 16. IL-4 is a cytokine which stimulates which type of macrophage activation
  11. 17. What cytokine enhances the activation, proliferation and survival of neutrophils and is associated with mucosal immunity?
  12. 19. cell deficiency absence of the common gamma chain of the IL2 receptor causes what?