Immunodeficiencies

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Across
  1. 4. recurrent "cold" staphylococcal infections (due to impaired recruitment of neutrophils), unusual eczema-like skin rashes, severe lung infections that result in pneumatoceles and very high (> 2000 IU/mL or 4800 mcg/L) concentrations of a specific antibody (3 words)
  2. 5. Slow decline in all classes of immunoglobulins; onset usually 10-30 years old (3 words)
  3. 7. mutation in signaling lymphocyte activation molecule rendering patients unable to effectively respond to Epstein-Barr virus (EBV) (3 words)
  4. 8. Autosomal recessive mutation on 22q causing deficient IgA and variable T cell dysfunction lading to progressive loss of coordination, malignancy, and immunodeficiency (2 words, hyphenated)
  5. 10. Profound lack of antibody due to mutation in a tyrosine kinase (2 words)
  6. 12. Defect in protein normally involved in actin rearrangement/branching causing poor antibody formation, poor T cell function, thrombocytopenia, eczema, and recurrent infection; x-linked (2-3 words)
  7. 15. Most common primary immunodeficiency; may have recurrent mucosal infections (2 words)
  8. 17. Term for low number of neutrophils, may predispose to severe infection (1 word)
  9. 18. Mutations resulting in deficient NADPH oxidase activity leading to recurrent bacterial infection (3 words)
  10. 19. condition due to impaired antibody class switching resulting in low IgA and IgG levels with normal or elevated IgM resulting in recurrent pyogenic infection (4 words)
  11. 20. Marked reduction in both T and B cell numbers, leading to severe immune dysfunction; either autosomal recessive (60%) or X-linked recessive (3 words)
Down
  1. 1. 4 live vaccines (1 acronym followed by 3 words)
  2. 2. Abnormal delay in onset of immunoglobulin synthesis (4 words)
  3. 3. defect WBC surface glycoproteins (CD11/CD18) resulting in recurrent infection beginning in neonatal period such as omphalitis, pneumonia, gingivitis, and peritonitis which may be life-threatening due to the infant's inability to properly destroy the invading pathogens (3 words)
  4. 6. mutation most commonly in the C1 inhibitor protein resulting in increased levels of bradykinin causing recurrent attacks of severe swelling; swelling most commonly affects the arms, legs, face, intestinal tract, and airway (2 words)
  5. 9. When you lack one or more subtypes of the most prominent antibody (3 words)
  6. 11. Recurrent candidal infections caused by abnormal T cell function (3 words)
  7. 13. Mutation of a lysosomal trafficking regulator protein, which leads to a decrease in phagocytosis; the decrease in phagocytosis results in recurrent pyogenic infections, albinism, and peripheral neuropathy (2-3 words, hyphenated)
  8. 14. Only antibody capable of crossing placenta (1 word)
  9. 16. Constellation of symptoms resulting from abnormal third and fourth pharyngeal pouch development resulting in a lack of a thymus and poor T cell function (2 words)