Across
- 2. Regulate the immune system; downstream effects include activation of macrophages, inflammation, and stimulation of T & B lymphocytes.
- 3. Epithelium, phagocytic cells, dentric cells, natural killer cells are components.
- 4. Kill cells harboring microbes.
- 6. Type I hypersensitivity reaction; examples include anaphylaxis, hay fever, food allergies.
- 9. Malformation leading to absence of thymus, leading to deficient T cell maturation.
- 13. Tissue graft where the donor is of the same species, but genetically not identical.
- 14. Type IV hypersensitivity reaction; Examples include contact dermatitis, type 1 diabetes, inflammatory bowel disease.
- 15. Special stain used to detect amyloid in tissues.
- 17. Type II hypersensitivity reaction; examples include Grave disease and erythroblastosis fetalis.
- 21. Association with system sclerosis, may precede other symptoms in 70% of cases.
- 23. Reservoirs of HIV infection in late-stage disease.
- 26. Process by which self-reacting cells are removed from circulation or inactivated.
- 28. Antibodies against this protein are specific for rheumatoid arthritis.
- 29. Secreted antibody, found in saliva, mucous, breast milk, serum, intestinal fluid.
- 34. Characterized by very low CD4 + T cells, high viral load, and opportunistic infections.
- 35. Rejection reaction that occurs immediately upon reperfusion of blood through graft tissue, mediated by IgM antibodies for blood group antigens - uncommon.
- 36. Differentiate into plasma cells in order to produce large quantities of antibodies.
- 40. Type cleft observed in biopsy sections of pemphigus vulgaris.
- 41. Mass of edematous synovium, inflammatory cells, and granulation tissue in the joint space of patients affected by rheumatoid arthritis.
- 43. Aggregates of abnormal fibrils composed of misfolded proteins in beta-pleated sheet conformation.
- 44. Rejection reaction occurring days-weeks post-transplant, mediated by host T cells activated by alloantigens in the graft.
- 46. Hereditary defect characterized by absent or decreased B cells.
- 48. RNA retrovirus
- 50. Clinical finding that can mark the transition to AIDS.
- 51. Caused by HHV8, strongly associated with HIV infection.
- 52. Ragged oral ulcerations, fishnet-appearing direct immunofluorescence, serology positive for anti-desmoglein 1&3.
- 53. Ex: lymph nodes, spleen, mucosal tissue; antigen processing centers where T and B cells can be exposed to high numbers of antigens.
- 54. Kill tumor and viral cells without prior sensitization.
- 55. A characteristic skin finding in systemic lupus erythematosus.
- 56. Antibodies against this protein are specific for systemic sclerosis.
Down
- 1. Rejection reaction occurring over months-years that results in interstitial fibrosis and narrowing of graft blood vessels.
- 3. Antibody that functions in allergies & parasitic infection.
- 5. Inflammation, antiviral defense, stimulates adaptive immune response.
- 7. Type III hypersensitivity reaction; examples include glomerulonephritis, rheumatoid arthritis, SLE.
- 8. Most common antibody, crosses placenta.
- 10. Desquamative gingivitis, intact oral vesicles, diagnosis by positive direct immunofluorescence.
- 11. Most common primary immune disease, usually asymptomatic.
- 12. Antibody of mystery.
- 16. Pathologic condition associated with hematopoeitic stem cell transplantation, acute & chronic forms, often oral involvement.
- 17. T cells and B cells are components.
- 18. Most efficient antigen-presenting cell (APC)
- 19. Autoimmune disease with a highly variable presentation, characterized by the production of multiple autoantibodies, including antibodies against dsDNA and Sm.
- 20. Finding on tongue strongly associated with HIV infection.
- 22. Typical prognosis for generalized amyloidosis.
- 24. Region of U.S. with the highest risk of HIV contraction.
- 25. Type of cleft observed in biopsy sections of mucous membrane pemphigoid.
- 27. Coreceptor necessary for HIV entry into T cells.
- 30. Xerostomia, parotid enlargement, keratoconjunctivitis, increase risk for lymphoma.
- 31. Secreted proteins that mediate immune and inflammatory reactions.
- 32. Scar tissue formation between bulbar and palpebral conjunctiva seen in MMP.
- 33. Viral protein of HIV that attaches to CD4 on T cells to gain entry into the cell.
- 37. Releases vasoactive amines, lipid mediators, cytokines when encountering an antigen for which it has been sensitized.
- 38. Area of the world with the greatest number of HIV-infected individuals.
- 39. Tissue graft where the donor is the same as the recipient.
- 42. Type of amyloidosis associated with a variety of underlying inflammatory conditions, better prognosis, tx involves managing underlying condition.
- 45. Basic pathogenesis is tissue damage and functional compromise in areas of deposition.
- 47. Largest antibody, first synthesized.
- 49. Tissue graft where the donor is genetically identical to the recipient.