Across
- 1. Autoimmune regulator: a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 3. Major histocompatibility complex: designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
- 5. Member of TNF receptor family expressed on certain cells that makes them susceptible to
- 7. A cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 10. a type of APC that presents antigen in the context of MHC to T cells
- 11. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
- 13. Family names of chemokines, chemicals that are a sub-class of cytokines with cell-attractant properties
- 15. large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses and can act as an effector cell in adaptive immune responses
- 18. NuclearfactorκB transcription factor that helps activate the expression of many pro-inflammatory genes
- 20. cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells
- 22. adaptive immune responses in which there is a major role for effector T cells
- 23. sIg on B cells that binds Ag and transmits signal 1 to activate B cells
Down
- 2. Immunoreceptor tyrosine-based activation motifs: amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
- 4. Acute phase protein that binds to phoshocholine, a constituent of certain bacteria that trigger complement activation and acts as an opsonin
- 5. Fragment with antigen binding: the part of an antibody (that can be isolated by protease digestion) responsible for antigen binding, consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
- 6. Natural killer cell: large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells (virally infected cells or tumor cells)
- 7. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
- 8. designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
- 9. Human leukoC gene complex and proteins in humans
- 12. Toll-like receptor: a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
- 14. Nuclear factor of activated T cells: a key transcription factor that is required to bind to the IL-2 promoter to cause IL-2 transcription
- 15. Mannose-binding lectin: soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of Complement and acts as an opsonin
- 16. Family names of chemokine receptors, the receptors that chemokines bind to all cell attraction to specific areas in the body
- 17. Immunoglobulin secreted by plasma cells
- 19. lipopolysaccharide: a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 21. Membrane attack complex: end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis