Immunology

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Across
  1. 1. Transcription factor expressed in Treg cells that is needed for Treg cell function
  2. 2. a T cell subset that is responsible for suppressing or limiting immune responses
  3. 6. what does IR stand for?
  4. 8. immunoglobulin secreted by plasma cells
  5. 11. name of MHC gene complex and proteins in humans
  6. 13. this is where Fc receptors bind, and so is responsible for antibody effector function (after antigen binding occurs)
  7. 14. the Ag receptor on T cells
  8. 17. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
  9. 18. protein family to which antibodies and B-cell receptors belong
  10. 20. an immunoglobulin that is expressed on B cell surface
  11. 21. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
  12. 24. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
  13. 26. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the Fas ligand
  14. 29. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  15. 30. chemicals that are a sub-class of cytokines with cell-attractant properties
  16. 32. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
  17. 33. designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
Down
  1. 1. the part of an antibody (that can be isolated by protease digestion) responsible for antigen binding, consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
  2. 3. the end stage of disease in HIV infection
  3. 4. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells (virally infected cells or tumor cells)
  4. 5. adaptive immune responses in which there is a major role for effector T cells
  5. 7. T cells that express the co-receptor protein CD8 which upon activation differentiate into cytotoxic T lymphocytes (CTLs)
  6. 9. this fragment of antibody consists of the carboxy terminal halves of the two heavy chains disulfide-bonded to each other
  7. 10. a type of APC that presents antigen in the context of MHC to T cells
  8. 12. family name for cytokines that help cells to resist viral infections; type 1 interferons include IFN-alpha and IFN-beta, as distinguished from IFN-gamma
  9. 15. acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger Complement activation and acts as an opsonin
  10. 16. white blood cells with multi-lobed nuclei and cytoplasmic granules
  11. 19. multiple drug treatment for HIV infection
  12. 22. cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells
  13. 23. end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  14. 25. T cells that express the co-receptor protein CD4 which upon activation differentiate into distinct Thelper phenotypes with different roles in adaptive immunity
  15. 27. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
  16. 28. large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses and can act as an effector cell in adaptive immune responses
  17. 31. thymus-derived lymphocyte that are comprised of two different subsets, CD4 T cells and CD8 T cells