Across
- 3. repeating molecular patters on microbes that are recognized by PRRs on immune cells
- 4. can differentiate into plasma cells secreting antibody molecules or B memory cells
- 6. subset of CD4+ T cells; involved in stimulating B cells to produce antibody against extracellular pathogens
- 9. membrane attack complex: end product of Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 11. specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
- 12. immunoglobulin secreted by plasma cells
- 13. member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the Fas ligand
- 14. subset of CD4+ T cells; involved in fully activating macrophages and promoting CTL responses against intracellular pathogens
- 16. immunoglobulin, protein family to which antibodies and B-cell receptors belong
- 18. Regulatory CD4+ T cells (regulatory T cells): a T cell subset that is responsible for suppressing or limiting immune responses
- 20. transcription factor expressed in Treg cells that is needed for Treg cell function
- 21. cell present antigen via MHC molecules to T cell receptors on T cells
- 24. toll-like receptor: a family of PRRs present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
- 25. large granular lymphocyte that serves as innate effector cell by inducing apoptosis of target cells (virally infected cells or tumor cells)
- 26. family for cytokines that help cells to resist viral infections
- 27. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 28. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
- 30. autoimmune regulator
Down
- 1. multiple drug treatment for HIV infection
- 2. cell surface molecules involved in presentation of peptide antigens to T cells
- 5. thymus derived lymphocyte that are comprised of 2 different subsets, CD4 T cells and CD8 T cells
- 7. IR
- 8. expresses co-receptor CD4 and upon activation differentiates into distinct Thelper phenotypes with different roles in adaptive immunity
- 10. cell adhesion molecule
- 15. upon activation differentiate into cytotoxic T lymphocytes (CTLs)
- 17. cell mediated immunity: adaptive immune responses in which there is a major roll for effector T cells
- 19. systemic lupus erythematosus: autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes
- 22. slg on B cells that binds Ag and transmits signal 1 to activate B cells
- 23. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 29. tumor necrosis factor-alpha: a cytokine produced by macrophages and T cells that is highly pro-inflammatory