Across
- 4. A mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
- 7. Repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 8. The regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
- 11. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
- 14. Adaptive immune responses in which there is a major role for effector T cells
- 17. A cell wall component of gram-negative bacteria which can be bound by toll-like receptor-4 on macrophages and dendritic cells
- 18. Receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 19. The antigen receptor on T cell
- 20. General designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
- 23. A T cell subset that is responsible for suppressing or limiting immune responses
- 24. Name of the major histocompatibility gene complex and proteins in humans
- 26. Soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of Complement and acts as an opsonin
- 30. A transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 32. A molecule that is recognized in native (original) structure by antibodies or B cell receptor
Down
- 1. Abbreviation for the multiple drug treatments for HIV infection
- 2. The designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
- 3. Surface immunoglobulin on B cells that binds antigen and transmits signal 1 to activate B cells
- 4. A cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 5. Acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger Complement activation and acts as an opsonin
- 6. Thymus-derived lymphocyte that are comprised of two different subsets, CD4 T cells and CD8 T cells
- 9. Family name for cytokines that help cells to resist viral infections
- 10. Autoimmune disease where autoantibodies (against DNA, RNA, and proteins associated with nucleic acids) form immune complexes
- 12. An immunoglobulin that is expressed on B cell surface
- 13. The end stage of disease in HIV infection
- 15. Large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses
- 16. Subset of CD4+ T cells characterized by the cytokines they produce; involved in stimulating B cells to produce antibody against extracellular pathogens
- 20. Amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
- 21. The part of an antibody responsible for antigen binding, consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
- 22. White blood cells with multi-lobed nuclei and cytoplasmic granules
- 25. Immunoglobulin secreted by plasma cells
- 27. An autoimmune disease where autoantibodies against DNA, RNA, and proteins associated with nucleic acids form immune complexes
- 28. Protein family to which antibodies and B-cell receptors belong
- 29. Transcription factor expressed in Treg cells that is needed for Treg cell function
- 31. End product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 33. The antigen receptor on T cells