Immunology Acronyms

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Across
  1. 1. Designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
  2. 11. The part of an antibody (that can be isolated by protease digestion) responsible for antigen binding, consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
  3. 14. The end stage of disease in HIV infection
  4. 16. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
  5. 17. Immune response
  6. 18. Immunoglobulin secreted by plasma cells
  7. 19. B cell receptor: sIg on B cells that binds Ag and transmits signal 1 to activate B cells
  8. 21. Large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells (virally infected cells or tumor cells)
  9. 22. a family of Pattern Recognition Receptors present on manyleukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
  10. 23. A mechanism NK cells usea molecule that is recognized in native (original) structure by antibodies
  11. 24. A transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
  12. 25. General designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
Down
  1. 2. Protein family to which antibodies and B-cell receptors belong
  2. 3. Short DNA sequences flanking Ig and TCR V, Dand J gene segments that serve as the binding sites for the RAG complex, allowingIg and TCR gene rearrangement (somatic recombination)
  3. 4. The two genes essential for Ig and TCR generearrangement; their gene products (RAG-1 & RAG-2) comprise the RAG complex
  4. 5. Name of MHC gene complex and proteins in humans
  5. 6. A cell that is able to present antigen via MHC molecules toT cell receptors on T cells
  6. 7. An immunoglobulin that is expressed on B cell surface
  7. 8. Multiple drug treatment for HIV infection
  8. 9. End product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
  9. 10. Cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells
  10. 12. Autoimmune disease where autoantibodies (againstDNA, RNA, and proteins associated with nucleic acids) form immune complexes
  11. 13. Adaptive immune responses in which there is a major role for effector T cells
  12. 15. Family name for cytokines that help cells to resist viral infections; type 1 interferons include IFN-alpha and IFN-beta, as distinguished from IFN-gamma.
  13. 20. A type of APC that presents antigen in the context of MHC to T cells