Immunology Activity 10.02.22

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Across
  1. 3. Amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
  2. 5. a cytokine produced by macrophages and T cells that is highly pro-inflammatory (be specific)
  3. 11. A type of leukocyte with multi-lobed nuclei and cytoplasmic granules
  4. 14. A cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  5. 15. The "A" in immunological CAM
  6. 20. Protein family to which antibodies and B-cell receptors belong
  7. 22. An immunoglobulin secreted by plasma cells
  8. 23. The T in ITAM
  9. 25. A family of pattern recognition receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
  10. 27. Membrane attack complex is the end product of the ______ cascade
  11. 30. The first P in PAMP and a microorganism that can cause disease
  12. 31. Natural killer cells are a type of large ____ lymphocyte
Down
  1. 1. The M in ITAM
  2. 2. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
  3. 4. A sugar on pathogens that MBL binds
  4. 6. Site of T cell education and development
  5. 7. This constituent of some bacteria is what the acute phase C-reactive protein binds
  6. 8. Large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of tumor cells or virally infected cells
  7. 9. Name of MHC gene complex and proteins in humans
  8. 10. Chemicals that are a sub-class of cytokines with cell-attractant properties; e.g. CCL or CXCL
  9. 12. This type of immune response involving effector T cells describes cell mediated immunity
  10. 13. The Ag receptor on T cells
  11. 16. An immunoglobulin that is expressed on B cell surface
  12. 17. A type of APC that presents antigen in teh context of MHC to T cells
  13. 18. A key transcription factor that is required to bind to the IL-2 promotor to cause IL-2 transcription
  14. 19. Abbreviation for the end stage of disease in HIV infection
  15. 21. Systemic ___ erythematosus is an autoimmune disease where autoantibodies form immune complexes
  16. 24. The N in TNF
  17. 26. Family name for cytokines that help cells to resist viral infections
  18. 28. Large mononuclear phagocyte found in many tissues and organs; involved in innate immune responses
  19. 29. Leukocytes are a type of ____ blood cell