Immunology Activity 10.02.22

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Across
  1. 4. Family name for cytokines that help cells to resist viral infections
  2. 7. Large mononuclear phagocyte found in many tissues and organs; involved in innate immune responses
  3. 11. The "A" in immunological CAM
  4. 13. The T in ITAM
  5. 14. Name of MHC gene complex and proteins in humans
  6. 16. A key transcription factor that is required to bind to the IL-2 promotor to cause IL-2 transcription
  7. 17. The first P in PAMP and a microorganism that can cause disease
  8. 19. A type of leukocyte with multi-lobed nuclei and cytoplasmic granules
  9. 21. Amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
  10. 23. Abbreviation for the end stage of disease in HIV infection
  11. 25. a cytokine produced by macrophages and T cells that is highly pro-inflammatory (be specific)
  12. 26. This constituent of some bacteria is what the acute phase C-reactive protein binds
  13. 28. The Ag receptor on T cells
  14. 29. Protein family to which antibodies and B-cell receptors belong
  15. 31. A type of APC that presents antigen in teh context of MHC to T cells
Down
  1. 1. A sugar on pathogens that MBL binds
  2. 2. Chemicals that are a sub-class of cytokines with cell-attractant properties; e.g. CCL or CXCL
  3. 3. Systemic ___ erythematosus is an autoimmune disease where autoantibodies form immune complexes
  4. 5. Membrane attack complex is the end product of the ______ cascade
  5. 6. Natural killer cells are a type of large ____ lymphocyte
  6. 8. Large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of tumor cells or virally infected cells
  7. 9. A cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
  8. 10. Site of T cell education and development
  9. 12. The N in TNF
  10. 15. This type of immune response involving effector T cells describes cell mediated immunity
  11. 18. An immunoglobulin secreted by plasma cells
  12. 20. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
  13. 22. The M in ITAM
  14. 24. A family of pattern recognition receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
  15. 27. Leukocytes are a type of ____ blood cell
  16. 30. An immunoglobulin that is expressed on B cell surface