Across
- 2. cells surface ligands for the leukocyte integrins; critical in binding of lymphocytes and other leukocytes to certain cells
- 5. acronym for an amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
- 9. leukocytes white blood cells with multi-lobed nuclei and cytoplasmic granules
- 11. T cells that express the co-receptor protein CD4 which upon activation differentiate into distinct T helper phenotypes with different roles in adaptive immunity
- 12. acronym for fragment with antigen binding
- 13. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
- 15. crystallized fragment of antibody
- 16. acronym for highly active anti-retroviral therapy
- 17. immunoglobulin secreted by plasma cells
- 19. acronym for nuclear factor of activated T cells
- 22. T cells that express the co-receptor protein CD8 which upon activation differentiate into cytotoxic T lymphocytes (CTLs)
- 23. family name for cytokines that help cells to resist virals infections - type 1 interferons include IFN-alpha and IFN-beta, as distinguished from IFN-gamma
- 25. acronym for family names of chemokine - chemicals that are a sub-class of cytokines with cell-attractant properties
- 27. acronym for cytotoxic T lymphocytes
- 28. adaptive immune responses in which there is a major role for effector T cells
- 29. Toll-like receptor
- 30. thymus-derived lymphocyte that are comprised of two different subsets - CD4 T cells and CD8 T cells
- 32. acute phase protein thats binds to phosphocholine, a constituent of a certain bacteria, that can trigger Complement activation and acts as an opsonin
- 37. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 39. transcription factor expressed in Treg cells that is needed for Treg cell function
- 40. acronym for family names of chemokine receptors - the receptors that chemokines bind to all cell attraction to specific areas in the body
- 42. a type of APC that presents antigen in the context of MHC to T cells
Down
- 1. an immunoglobulin that is expressed on B cell surface
- 3. the regions of the antigen binding loops of Ig molecules, antibodies, and T cell receptors that come into contact with antigen
- 4. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
- 6. acronym for pathogen associated molecular patterns
- 7. what is MAC an acronym for?
- 8. acronym for receptors on immune cells and epithelial cells that recognize and bid to PAMPs on microbes
- 10. acronym for autoimmune disease where autoantibodies (against DNA RNA and proteins associated with nucleic acids) form immune complexes
- 14. general designation of many of the different cytokines - chemical messengers secreted by immune cells that help in their communication with other cells
- 18. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 20. Member of TNF receptor family express on certain cells that makes them susceptible to being killed by cells expressing the Fas ligand
- 21. acronym for antibody dependent cellular cytotoxicityantigen a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
- 24. acronym for mannose-binding lectin
- 26. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells
- 27. acronym for cluster of differentiation
- 31. T-cell receptor: the Ag receptor on T cells
- 33. acronym for cell adhesion molecule
- 34. leukocyte antigen, name of MHC gene complex and protein in humans
- 35. acronym for immune response
- 36. acronym for immunoglobulin
- 38. acronym for acquired immune deficiency syndrome
- 41. human immunodeficiency virus
- 43. acronym for recombination signal sequences