Across
- 2. The Ag receptor on T cells
- 4. Human immunodeficiency virus
- 6. name of MHC gene complex and proteins in human
- 7. a molecule that is recognized in native structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
- 8. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 10. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 11. acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger Complement activation and acts as an opsonin
- 13. Family of pattern recognition receptors present on many leukocytes and epithelial cells that recognize PAMPs and help initiate immune responses
- 15. family name for cytokines that help cells to resist viral infections
- 16. amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
- 19. thymus-derived lymphocyte that are comprised of two different subsets: CD4 T-cells and CD8 T-cells
- 21. Member of the TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the Fas ligand
- 22. cells surface ligands for the leukocyte integrins
- 24. short DNA sequences flanking Ig and TCR V, D and J gene segments; serve as the binding sites for the RAG complex
- 26. immunoglobulin secreted by plasma cells
- 27. large granular lymphocyte that serves as an innate effector cells by inducing apoptosis of target cells
- 29. protein family to which antibodies and B-cell receptors belong
- 30. a type of Ac
- 31. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
- 34. CD8+ T cells with effector function of targeting and killing virally infected cells and tumor cells by apoptosis
- 35. soluble acute phase response protein that can bind mannose on pathogens
- 37. slg on B cells that binds Ag and transmits signal 1 to activate B cells
Down
- 1. immune response
- 3. adaptive immune responses in which there is a major role for effector T cells
- 4. multiple drug treatment for HIV infection
- 5. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 9. family names of chemokine receptors, the receptors that chemokines bind to all cell attraction to specific areas in the body
- 10. white blood cells with multi-lobed nuclei and cytoplasmic granules
- 12. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 14. the end stage of disease in HIV infection
- 17. end product of the complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 18. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
- 20. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 21. the part of an antibody responsible for antigen binding
- 23. autoimmune disease where autoantibodies form immune complexes
- 25. an immunoglobulin that is expressed on B cell surface
- 26. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
- 28. cell adhesion molecule
- 32. family names of chemokines, chemicals that are a sub-class of cytokines with cell-attractant properties
- 33. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
- 36. slg on B cells that binds Ag and transmits signal 1 to activate B cells
- 38. designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another