Across
- 1. cell adhesion molecule
- 4. “Cytotoxic T lymphocytes”: CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
- 6. “Cell mediated immunity”: adaptive immune responses in which there is a major role for effector T cells
- 9. T cell, T cells that express the co-receptor protein CD8 which upon activation differentiate into cytotoxic T lymphocytes (CTLs)
- 10. “Human leukocyte antigen”: name of MHC gene complex and proteins in humans
- 12. “Complementarity determining regions”: the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
- 14. “Acquired immune deficiency syndrome”: the end stage of disease in HIV infection
- 16. Transcription factor expressed in Treg cells that is needed for Treg cell function
- 18. “Cluster of differentiation”: designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
- 19. “Human Immunodeficiency Virus”
- 21. “Mannose-binding lectin”: soluble acute phase response protein that can bind mannose on pathogens; can activate the lectin pathway of Complement and acts as an opsonin
Down
- 2. “Major histocompatibility complex”: designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
- 3. “Interleukin”: general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
- 5. “lipopolysaccharide”: a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 6. T cell, T cells that express the co-receptor protein CD4 which upon activation differentiate into distinct Thelper phenotypes with different roles in adaptive immunity
- 7. “Immunoglobulin”, protein family to which antibodies and B-cell receptors belong
- 8. “Dendritic cell”: a type of APC that presents antigen in the context of MHC to T cells
- 10. “Highly active anti-retroviral therapy”: multiple drug treatment for HIV infection
- 11. “Antigen”: a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
- 13. “C-reactive protein”: acute phase protein that binds to phosphocholine, a constituent of certain bacteria, that can trigger Complement activation and acts as an opsonin
- 14. “Antibody”: immunoglobulin secreted by plasma cells
- 15. “Nuclear factor of activated T cells”: a key transcription factor that is required to bind to the IL-2 promoter to cause IL-2 transcription
- 17. “Antibody dependent cellular cytotoxicity”: a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
- 20. “Immune Response”