Immunology Midterm 2

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Across
  1. 3. _____ positive T cell express both CD4 and CD8.
  2. 5. Adhesion molecules act as _____ to coordinate travel of lymphocytes between human tissue and secondary lymphoid organs.
  3. 7. PD-1 is expressed on the surface of T cells and inhibits T cells ________ in order to terminate the immune response.
  4. 10. This type of T cell (4 letter abbreviation) helps to regulate self reactive T cells that could cause autoimmune disease.
  5. 12. _______ chain genes of the B cells are rearranged if the receptors fail testing in bone marrow.
  6. 13. This is where T cells are found in the lymph node.
  7. 14. This type of selection asks T cells if they can sense a self-peptides being presented on an MHC molecule.
  8. 16. Peripheral tolerance induction results in death or ______.
  9. 17. The _____ zone occurs in the germinal center, where B cells proliferate and undergo hypermutation.
  10. 19. This process allow for "abnormal" Class 2 MHC molecule presentation.
  11. 22. This type of thymic epithelial cell is able to express thousands of tissue specific proteins.
Down
  1. 1. When T cells enter the thymus they are resistant to _____ because they do not express CD4 or CD8.
  2. 2. ____ positive cells are developed after positive selection.
  3. 4. Receptor ______ occurs in B cells if their receptors do not recognize self-antigen in the bone marrow.
  4. 5. After 5 days of this, a plasma B cell will die.
  5. 6. Neutrophils only live a few ____. (This answer is plural.)
  6. 8. This receptor causes T cells to have repressed re-activation.
  7. 9. The secondary lymphoid organs include lymph node, MALT and ____.
  8. 11. This type of dendritic cell tests for resistance to self-peptides in the thymus during negative selection.
  9. 15. This 4 letter abbreviation is the process by which T cells to commit suicide or homicide after they have been re-activated multiple times.
  10. 18. This type of cell death occurs when T cells are repeatedly activated and are targets for Fas-mediated killing.
  11. 20. This chemokine is produced by FDC's in the lymph node to attract naive B cells.
  12. 21. There is where Peter's Patches are located. (hint: 4 letter abbreviation)