Immunology Week 1

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Across
  1. 1. Killer, large granular lymphocyte cell that serves as an innate effector cell by inducing apoptosis of target cells (virally infected cells or tumor cells)
  2. 3. a T cell subset that is responsible for suppressing or limiting immune responses (abbreviation)
  3. 4. repeating molecular patterns on microbes that are recognized by PRRs on immune cells (abbreviation)
  4. 6. immunoglobulin secreted by plasma cells
  5. 11. family name for cytokines that help cells to resist viral infections; type 1 interferons include IFN-alpha and IFN-beta as distinguished from IFN-gamma.
  6. 12. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells (abbreviation)
  7. 13. secreted by immune cells that help in their communication with other cells
  8. 15. a transcription factor that causes several hundred tissue- specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
  9. 17. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells (abbreviation)
  10. 18. a cytokine produced by macrophages and T cells that is highly pro-inflammatory
Down
  1. 2. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells (abbreviation)
  2. 3. location where T cells mature
  3. 5. a molecule that is recognized in native (original) structure by antibodies or B cell receptor or a peptide that is presented by MHC molecules to T cell receptor
  4. 7. cell, B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
  5. 8. a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses (abbreviation)
  6. 9. Type of T cell with CD4+
  7. 10. general designation of many of the different cytokines or chemical
  8. 11. cells surface ligands for the leukocyte integrins; Critical in binding of lymphocytes and other leukocytes to certain cells (abbreviation)
  9. 14. gene essential for Ig and TCR gene rearrangement
  10. 16. Subset of CD4+ T cells characterized by the cytokines they produce; involved in stimulating B cells to produce antibody against extracellular pathogens