In-Vitro techniques crossword puzzle

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Across
  1. 1. Inhibits GAT1 mediated GABA uptake non-competitively
  2. 3. PAM of the GABA receptor, anaesthetic
  3. 6. Negatively modulates NaV1.7
  4. 10. Antagonist of GABA receptor, orthosteric binding
  5. 12. potent, non-selective GABA-A agonist. An othosteric ligand
  6. 13. Ion-channel blocker that specifically blocks Na+ selective ionchannels
  7. 14. A small-molecule chaperone that increases GCase protein levels and activity
  8. 17. GlyR inhibitor
  9. 18. inhibits phosphodiesterase
  10. 19. Positive Allosteric Modulator of GABA receptor, involved in menstrual cycle
  11. 20. Activates Adenylate cyclase
Down
  1. 2. PAMs of the GABA-receptor. Increases GABA efficacy and channel opening time.
  2. 4. competitive antagonist of the b2AR
  3. 5. Full agonist of the b2-AR
  4. 7. Partial agonist of the b2AR
  5. 8. PAM of the GABA receptor. Increases receptor affinity.
  6. 9. PAMs of the GABA receptor
  7. 11. ion-channel blocker of GABA
  8. 14. Partial agonist of the b2AR
  9. 15. subtype specific agonist for GABA-A receptors, used for sleep disorder
  10. 16. Inhibits GAT1-mediated GABA uptake competitively