Influenza Virus

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Across
  1. 3. type of vaccine used for prevention of influenza virus
  2. 4. lab test used to diagnose influenza
  3. 5. infection with the influenza virus leads to increased _____ production
  4. 6. common clinical symptom characterized by abnormally high body temperature
  5. 8. antibody class mainly responsible for immune response to influenza
  6. 12. season in which influenza epidemics occur regularly
  7. 13. signaling protein released in response to infection with influenza virus
  8. 14. the _____ period for influenza virus is 18-72 hours
  9. 16. term influenza originated from the Italian word meaning ____
  10. 18. acid receptor molecule for influenza virus
  11. 20. most common complication of influenza
  12. 23. molecule consisting of protein and carbohydrates
  13. 26. occurs when new cases of a disease in a given population exceeds steady-state norm
  14. 27. drift minor change in properties of influenza virus that make existing vaccines less or noneffective
  15. 31. shift major change in the influenza virus which usually leads to global influenza pandemics
  16. 32. shape of hemagglutinin as seen from electron micrographs
  17. 33. type of antigenic shift involving segment exchange recombination
  18. 34. steady-state maintenance of infection rate in a population without external input
  19. 35. method by which viral components are released from the cell
  20. 36. structural motif found at the end of each vRNA segment
  21. 37. global outbreak
  22. 38. type of antigenic shift involving crossover recombination
  23. 39. M1 protein that forms rigid outer shell to protect the virus
  24. 40. process in which 2 or more viruses infect a single host and exchange genetic material
  25. 43. Flu major influenza pandemic which occurring in 1918
  26. 44. after endocytosis the virion fuses with the _____
  27. 45. common type of infection caused by influenza viruses
  28. 47. method of infection transmission
  29. 48. high _____ rates allow circumvention of the immune system
Down
  1. 1. trimeric glycoprotein found in the membrane envelope which assists in host cell attachment
  2. 2. member of this family
  3. 7. cells in which influenza viruses replicate
  4. 9. A type of influenza associated with pandemics
  5. 10. shape of the viral genome
  6. 11. type of virus in which the nucleocapsid is surrounded by a lipid bilayer
  7. 12. animal species that acts as a “natural reservoir” for influenza virus
  8. 15. type of RNA found in the genome
  9. 17. contained in the host nucleus, essential for mRNA viral synthesis
  10. 18. structure of virus genome
  11. 19. age group with highest rate of infection
  12. 21. enzyme which catalyzes glycosidic breakdown and assists viral exit from the host cell after multiplication
  13. 22. number of viral proteins encoded by the genome
  14. 24. enzyme inhibited by therapeutic agents such as Tamiflu
  15. 25. first individual to describe influenza-like symptoms as early as 412 B.C.
  16. 28. influenza virus is divided into __ major classes
  17. 29. variable in size and shape
  18. 30. shape of capsid
  19. 41. number of segments in the viral genome
  20. 42. how often should influenza vaccines be administered
  21. 46. method of entry into the host cell