Innate Immune System

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Across
  1. 3. involved in the hypothalamic activation of fever
  2. 7. binds to ICAM on endothelial cells
  3. 8. prevents C9 from binding in MAC formation
  4. 10. a cytokine made by NK cells
  5. 12. can be dumped on by macrophages for invaders too large for phagocytosis
  6. 13. cytokine created by macrophages that target tumor and virus-infected cells
  7. 15. attached to inhibitory receptors to prevent NK cell from destroying target
  8. 16. kills tumor cells, virus-infected cells, fungi, bacteria, and parasites
  9. 18. an anti-body focused, fast-paced way that the complement system activates
  10. 21. one of the groups that Cb3 can attach to to make convertase
  11. 23. creates more complement proteins in a positive feedback loop
  12. 24. macrophage state when activated by LPS and/or mannose
  13. 25. proliferates more NK cells when its receptors are made on their surfaces
  14. 26. used for virus attacks
  15. 29. the spontaneous, protein-focused method that the complement system activates
  16. 30. when the macrophage becomes an antigen-presenting cell
  17. 31. pain, redness, heat
Down
  1. 1. recognize general invader traits + important, unmutable structures
  2. 2. used to recognize DAMPs + PAMPs
  3. 4. causes cell suicide via delivering granenzyme B in NK cells
  4. 5. part of the complement system; drills holds into the invader cells
  5. 6. targeted way that the complement system gets activated by using MBL
  6. 9. 20 proteins that destroy and signal immune system to attack
  7. 11. primarily where type I IFN-alpha and IFN-beta are made
  8. 14. can liquefy cells and tissues
  9. 17. made by the complement system (eg. C3a, C5a)
  10. 19. can induce fever in bacterial infections
  11. 20. C3bBb
  12. 22. "poor man antibody"
  13. 27. binds to selectin made by endothelial cells; on the neutrophil
  14. 28. the least amount of MHC II receptors are on macrophages at this state