INTRO - Drug Design, Discovery, and Development

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Across
  1. 2. compound Promising compound selected for further drug development
  2. 3. Process of testing compounds for a specific biological activity
  3. 6. Method that builds ligands within the binding pocket of a target
  4. 10. Structural features necessary for a drug to produce biological activity
  5. 13. Three-dimensional or chemical arrangement of atoms in a molecule
  6. 14. Molecule that binds to a receptor or biological target
  7. 15. Interaction between a drug molecule and its biological target
  8. 17. Effect produced by a drug or chemical compound in a biological system
  9. 19. Relationship between chemical structure and biological activity
  10. 22. Drug design approach using known active compounds as a basis
  11. 23. pocket Region of a protein where a ligand or drug molecule interacts
  12. 24. Computational method for modeling a target protein using a related protein
Down
  1. 1. Anti-inflammatory drug activated after metabolic reduction
  2. 4. screening Targeted approach that focuses on compounds with specific characteristics
  3. 5. Protein structure that binds a drug or ligand
  4. 7. group Specific group of atoms responsible for characteristic chemical properties
  5. 8. Technique that provides three-dimensional molecular information in liquid phase
  6. 9. Technique using X-rays to determine molecular structure
  7. 11. Process that chemically modifies a drug in the body
  8. 12. Process of modifying a lead compound to improve its activity
  9. 13. Drug design approach based on the three-dimensional structure of a target
  10. 16. Computational approach used to study drug-target interactions
  11. 18. Measure of the strength of a drug's biological effect
  12. 20. screening Method that tests compounds without considering their chemical structure
  13. 21. Ability of a compound to produce a biological effect