Across
- 3. general designation of many of the different cytokines, chemical messengers secreted by immune cells that help in their communication with other cells
- 6. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 7. Cell adhesion molecule
- 8. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 11. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 12. Human immunodeficiency virus
- 14. white blood cells with multi-lobed nuclei and cytoplasmic granules
- 15. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells
- 16. adaptive immune responses in which there is a major role for effector T cells
- 17. a type of APC that presents antigen in the context of MHC to T cells
- 20. multiple drug treatment for HIV infection
- 23. the part of an antibody (that can be isolated by protease digestion) responsible for antigen binding, consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
- 25. the regions of the antigen binding loops of Ig molecules, antibodies and T cell receptors that come into contact with antigen
- 29. end product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 30. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
Down
- 1. thymus-derived lymphocyte that are comprised of two different subsets
- 2. white blood cells with multi-lobed nuclei and cytoplasmic granules
- 3. immune response
- 4. soluble acute phase response protein that can bind mannose on pathogens
- 5. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 7. adaptive immune responses in which there is a major role for effector T cells
- 9. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the Fas ligand
- 10. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus
- 13. name of MHC gene complex and proteins in humans
- 18. family name for cytokines that help cells to resist viral infections
- 19. large mononuclear phagocyte that takes residence in many different tissues and organs and contributes to innate immune responses and can act as an effector cell in adaptive immune responses
- 21. Plasma cells secrete this immunoglobullin
- 22. a family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
- 24. a molecule that is recognized in native (original) structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell receptor
- 26. the Ag receptor on T cells
- 27. a cytokine produced by macrophages and T cells that is highly pro-inflammatory
- 28. a type of APC that presents antigen in the context of MHC to T cells