Across
- 3. large granular lymphocyte that serves as an innate effector cell by inducing apoptosis of target cells(virally infected cells or tumor cells)
- 4. immunoglobulin secreted by plasma cells
- 5. a mechanism NK cells use to induce apoptosis in virally infected cells or tumor cells
- 7. designation for specific cell-surface molecules on immune cells that help to differentiate one immune cell from another
- 8. type of APC that presents antigen in the context of MHC to T cells
- 9. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
- 10. amino acid sequence in cytoplasmic domains of membrane receptors involved in signal transduction
- 13. white blood cells with multi-lobed nuclei and cytoplasmic granules
- 14. family name for cytokines that help cells to resist viral infections(type 1 interferons include IFN-alpha and IFN-beta as distinguished from IFN-gamma)
- 16. sIg on B cells that binds Ag and transmits signal 1 to activate B cells
- 17. and product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis
- 20. designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells
- 23. cells surface ligands for the leukocyte integrins
- 24. a cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells
- 25. the Ag receptor on T cells
- 26. a cell that is able to present antigen via MHC molecules to T cell receptors on T cells
- 28. the regions of the antigen binding loops of Ig molecules or antibodies and T cell receptors that come into contact with antigen
- 29. T cell subset that is responsible for suppressing or limiting immune responses
- 30. soluble acute phase response protein that can bind mannose on pathogens and can activate the lectin pathway of Complement and acts as an opsonin
- 33. an immunoglobulin that is expressed on B cell surface
- 34. family names of chemokines or chemicals that are a sub-class of cytokines with cell-attractant properties
- 35. name of MHC gene complex and proteins in humans
- 37. short DNA sequences flanking Ig and TCR V and D and J gene segments that serve as the binding sites for the RAG complex and allow Ig and TCR gene rearrangement(somatic recombination)
Down
- 1. the part of an antibody that consists of the carboxy terminal halves of the two heavy chains disulfide-bonded to each other or the Fc region of an antibody is where Fc receptors bind and so is responsible for antibody effector function (after antigen binding occurs)
- 2. general designation of many of the different cytokines chemical messengers secreted by immune cells that help in their communication with other cells
- 3. transcription factor that helps activate the expression of many pro-inflammatory genes
- 4. the end stage of disease in HIV infection
- 6. acute phase protein that binds to phosphocholine otherwise known as a constituent of certain bacteria, that can trigger Complement activation and acts as an opsonin
- 7. adaptive immune responses in which there is a major role for effector T cells
- 11. a cytokine produced by macrophages and T cells that is highly pro-inflammatory
- 12. the part of an antibody (that can be isolated by protease digestion) responsible for antigen binding and consisting of the light chain and amino-terminal half of the heavy chain disulfide-bonded together
- 14. immune response
- 15. key transcription factor that is required to bind to the IL-2 promoter to cause IL-2 transcription
- 18. member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing the Fas ligand
- 19. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
- 21. multiple drug treatment for HIV infection
- 22. family of Pattern Recognition Receptors present on many leukocytes and epithelial cells that recognize PAMPs on pathogens and help initiate immune responses
- 23. protein family to which antibodies and B-cell receptors belong
- 25. thymus-derived lymphocyte that are comprised of two different subsets (CD4 T cells and CD8 T cells)
- 26. a molecule that is recognized in native structure by antibodies or B cell receptor, or a peptide that is presented by MHC molecules to T cell
- 27. cell adhesion molecule
- 28. CD8+ T cells with the effector function of targeting and killing virally infected cells and tumor cells by apoptosis
- 31. B lymphocyte that upon activation can differentiate into plasma cells secreting antibody molecules or B memory cells
- 32. family names of chemokine receptors or the receptors that chemokines bind to all cell attraction to specific areas in the body
- 33. autoimmune disease where autoantibodies(against DNA and RNA and proteins associated with nucleic acids) form immune complexes
- 35. Human immunodeficiency virus
- 36. a transcription factor that causes several hundred tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus