Across
- 3. metabolized by CYP3A4 inhibit EGFR Tyrosine kinase
- 4. monitor LFR INR Pulmonary ocular toxicity
- 11. VEGF Inhibitor GI perforation Hemorrhage impaired wound healing leukopenia neutropenia
- 12. inhibits HDAC edema QT prolongation thrombocytopenia hepatoxic fever
- 13. diftitox delivers diphtheria toxin and IL2 to cells expressing IL2 receptor
- 15. side effects include GI perforation heart failure delayed open wound healing
- 16. binds to extracellular HER2
- 17. Inhibits delta Phosphatidylinositol 3-kinase severe Diarrhea Bowel perforation Hepatotoxicity
- 19. blocks activity at the 26S chromosome
- 20. Mesylate rash edema bone marrow suppression increase SCR
- 22. HepB reactivation tumor lysis syndrome
Down
- 1. HSV-1 virus that lyses tumor cells
- 2. contraindicated bilirubin >1.5x ULN
- 5. monitor vital signs during and up to 1 hour serum Mg Ca K every 8 weeks
- 6. Irreversible inhibitor of 20S proteosome
- 7. hedgehog inhibitor
- 8. severe diarrhea severe thrombocytopenia
- 9. mTor inhibitor
- 10. inhibits HDAC edema hyperglycemia QT prolongation pulmonary embolism
- 13. binds to BCR-ABL to prevent unregulated cell growth
- 14. CDK 4 and 6 inhibitor
- 18. hedgehog inhibitor increase serum creatine increase CK Rhabdo muscle/skeletal pain
- 21. reversibly inhibit beta 5 subunit of 20S proteosome