L20: Serotonin

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Across
  1. 2. a selective agonist of 5-HT1a receptors
  2. 3. a partial agonist of 5-HT2a receptors
  3. 6. a partial agonist of 5-HT2a receptors; found in “magic mushrooms”
  4. 7. product in the first step of serotonin synthesis; substrate in the 2nd step of serotonin synthesis
  5. 9. specific reuptake inhibitor for SERTs (10 letters)
  6. 10. a selective antagonist of 5-HT2a receptors; used to treat schizophrenia
  7. 13. (abbreviation) a selective agonist of 5-HT3 receptors
  8. 16. a selective agonist of 5-HT2c receptors
  9. 19. a non-selective antagonist of 5-HT2 receptors (11 letters)
  10. 20. a non-selective antagonist of 5-HT1 receptors
  11. 21. drug that affects VSERTs and SERTs; once marketed as a diet pill
  12. 22. a selective agonist of 5-HT1B and 5-HT1C receptors; used in migraine therapy (10 letters)
  13. 24. a non-selective antagonist of 5-HT2 receptors (11 letters)
  14. 26. the non-selective agonists for 5-HT receptors are 5-HT and ___
  15. 27. specific reuptake inhibitor for SERTs (10 letters)
  16. 29. a partial agonist of 5-HT2a receptors; a metabolite of a psychedelic found in “magic mushrooms”
  17. 30. (abbreviation) enzyme involved in the second step of serotonin synthesis; also called DDC
  18. 32. specific reuptake inhibitor for SERTs; marketed as Prozac
  19. 33. (abbreviation) a neurotoxin specific to 5-HT neurons
Down
  1. 1. a hormone produced by the pineal gland; a derivative of 5-HT
  2. 4. a selective agonist of 5-HT2a receptors
  3. 5. a selective antagonist of 5-HT2c receptors
  4. 8. a selective agonist of 5-HT1B and 5-HT1C receptors; used in migraine therapy (11 letters)
  5. 11. (abbreviation) enzyme involved in the first step of serotonin synthesis; the rate limiting enzyme
  6. 12. (abbreviation) 5-HT transporter that pumps serotonin in and out of the cell
  7. 14. a selective antagonist of 5-HT3 receptors
  8. 15. specific reuptake inhibitor for SERTs (11 letters)
  9. 17. 5-HT
  10. 18. a selective antagonist of 5-HT2b receptors
  11. 23. a non-selective antagonist of 5-HT6 and 5-HT7 receptors
  12. 25. specific reuptake inhibitor for SERTs; marketed as Zoloft
  13. 28. substrate in the first step of serotonin synthesis
  14. 31. (abbreviation) protein transporters responsible for packaging serotonin into vesicles