Landmark HTN/HF Trials

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Across
  1. 2. This 1987 study showed that enalapril decreased the progression of severe HF and mortality from it.
  2. 4. This 2001 study showed that losartan reduced the risk of developing ESRD in patients with diabetes
  3. 6. This 1991 study showed that enalapril was superior to hydralazine+isosorbide in terms of mortality reduction in HF patients.
  4. 7. This 2008 study showed that benazepril plus amlodipine was more effective than benazepril plus HCTZ at reducing cardiovascular events in high risk patients with HTN.
  5. 9. This 2014 study showed that valsartan-sacubitril reduced the risk of hospitalizations and death from HF
  6. 11. This 1999 study showed that metoprolol reduced mortality in patients with symptomatic HF.
  7. 12. This 2001 study showed that a LV assist device reduced all-cause mortality in patients in severe heart failure on optimal GDMT
  8. 15. This 2011 study showed that the dosage of loop diuretics had no significant effect on overall effectiveness or safety in acute decompensated HF.
  9. 17. This 1994 study showed that ivabradine reduced hospitalization and death from HF in patients with a baseline heart rate > 70.
  10. 18. This 1999 study showed that spironolactone reduced all-cause mortality in patients with LVEF <=35%
  11. 19. This 2009 study showed that cardiac resynchronization therapy, in addition to ICDs, reduced the risk of HF events in patients with HFrEF and prolonged QRS>130ms.
  12. 21. This 2015 study showed that an SBP target of 120 was superior to 140 in high-risk patients with HTN without DM.
Down
  1. 1. This 2010 study showed that intense BP control did not reduce rates of MI, stroke, CV mortality in patients with diabetes
  2. 3. This 2005 study showed that ICDs decreased mortality in patients with LVEF <=35% and NYHA II-III symptoms
  3. 5. This was the first randomized controlled trial of hypertension treatment anywhere in the world.
  4. 8. This 1997 study showed that a combination diet rich in fruits and vegetables and low in fat reduced blood pressure in comparison to the typical American diet.
  5. 10. This 2000 study demonstrated ramipril reducing CV events in high-risk patients without HFrEF
  6. 13. This 2002 study showed that the addition of carvedilol to standard severe heart failure (EF<25%) therapy resulted in significant mortal risk reduction.
  7. 14. This 2002 study established thiazides as the first-line therapy for hypertension
  8. 16. This 1999 study showed that high-dose ACE inhibitors reduced hospitalizations or death from HF compared to a lower dose.
  9. 20. This 1998 study showed that DBP goal of 80mmHg did not further reduce CV events than a DBP goal of 90.