Laug OSU Winter 2025 - Immunology Exam 2 Study Tool Week 4

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Across
  1. 3. The most common type of T cell receptor, recognizing MHC-presented peptides.
  2. 4. The interface where T cells form a connection with antigen-presenting cells for activation.
  3. 7. A fragment of the invariant chain that temporarily blocks the MHC II antigen-binding groove.
  4. 10. Proteins generated inside a cell, often degraded for Class I MHC presentation.
  5. 11. A molecule found on most nucleated cells that presents endogenous antigens to CD8 T cells.
  6. 14. Works with RAG1 to mediate V(D)J recombination in developing lymphocytes.
  7. 15. A molecule found on antigen-presenting cells that presents exogenous antigens to CD4 T cells.
  8. 17. Proteins taken up from the environment and processed for Class II MHC presentation.
  9. 19. A signaling molecule complex associated with T cell receptors for activation.
  10. 22. A molecule that removes CLIP, allowing proper antigen loading onto MHC II.
  11. 25. Works with TAP1 to transport antigenic peptides for MHC I presentation.
  12. 26. A second signal required for T cell activation to prevent anergic responses.
  13. 27. A co-receptor on helper T cells that binds MHC II.
  14. 28. A co-stimulatory molecule on APCs that binds CD28 to activate T cells.
  15. 29. The most potent antigen-presenting cells, crucial for initiating T cell responses.
  16. 31. An enzyme required for T and B cell receptor gene recombination.
  17. 32. The ability of dendritic cells to present exogenous antigens on MHC I to activate CD8 T cells.
  18. 33. A less common type of T cell receptor that can recognize non-MHC antigens.
Down
  1. 1. A major Class I MHC molecule important for antigen presentation to CD8 T cells.
  2. 2. A specialized T cell that recognizes lipid antigens presented by CD1 molecules.
  3. 5. Vesicles where MHC II molecules load peptides before reaching the cell surface.
  4. 6. Cells like dendritic cells, macrophages, and B cells that present antigens via MHC II.
  5. 8. Short chains of amino acids that can be presented as antigens by MHC molecules.
  6. 9. The organelle where MHC I molecules are assembled and loaded with peptides.
  7. 11. A receptor on T cells that binds B7 for co-stimulatory signaling.
  8. 12. A chaperone protein that blocks the MHC II binding site until it reaches the endosome.
  9. 13. A co-receptor on cytotoxic T cells that binds MHC I.
  10. 16. The compatibility of MHC molecules between individuals, crucial for organ transplants.
  11. 18. A Class I MHC molecule that helps present intracellular antigens to T cells.
  12. 20. A transporter protein that moves peptides into the endoplasmic reticulum for MHC I loading.
  13. 21. A non-MHC protein that stabilizes Class I MHC molecules on the cell surface.
  14. 23. Precursor cells to macrophages and dendritic cells, involved in immune responses.
  15. 24. A highly polymorphic Class I MHC molecule involved in immune recognition.
  16. 30. Protein complexes that degrade intracellular proteins into peptides for MHC I antigen presentation.