Across
- 2. The process in the thymus that ensures T cells can recognize self-MHC, occurring in the cortex.
- 3. A receptor that, when bound by FasL, initiates the apoptotic pathway in cells.
- 6. A process where cells degrade their own components, playing a role in self-antigen presentation in the thymus.
- 10. A checkpoint protein expressed on some cells that binds PD-1, helping suppress T cell activity and prevent overactive immune responses.
- 11. A transcription factor that allows mTECs to express tissue-specific proteins for negative selection.
- 12. A protein that binds Fas to trigger apoptosis in target cells, helping regulate the immune response.
- 15. Cells in the thymus that present self-antigens to developing T cells, aiding in negative selection.
- 16. A state in which a T cell becomes functionally inactive due to lack of co-stimulation.
- 18. A mechanism by which overactivated T cells undergo apoptosis to maintain immune homeostasis.
- 20. Specialized cells in the thymic cortex that present self-MHC molecules to developing T cells during positive selection.
- 22. The requirement that T cells recognize antigen only in the context of self-MHC molecules.
- 23. A type of T cell that develops outside the thymus and suppresses immune responses to prevent autoimmunity.
- 24. The outer region of the thymus where immature T cells undergo positive selection.
- 25. The process that eliminates T cells that bind too strongly to self-antigens, preventing autoimmunity.
- 27. Proteins usually found in specific organs, but expressed in the thymus for immune tolerance training.
- 28. The inner region of the thymus where negative selection occurs.
Down
- 1. The process by which developing T cells in the thymus are selected to prevent autoimmunity.
- 4. A T cell that has completed selection and expresses either CD4 or CD8, but not both.
- 5. Molecules like PD-1 and CTLA-4 that regulate immune activation and prevent excessive immune responses.
- 7. Cells in the thymic medulla that express self-antigens to help in negative selection.
- 8. A mechanism in B cells that modifies their antigen receptor to prevent self-reactivity.
- 9. A feature of NK cells, which attack cells that lack self-MHC molecules, such as virus-infected or cancerous cells.
- 13. A process that prevents self-reactive T cells from causing autoimmunity outside the thymus.
- 14. A receptor on T cells that, when bound to PD-L1, downregulates immune responses.
- 17. A checkpoint protein on T cells that competes with CD28 to bind B7, inhibiting immune activation.
- 19. A subset of T cells that develop in the thymus and suppress immune responses to maintain tolerance.
- 21. A stage of T cell development where thymocytes express both CD4 and CD8 before selection.
- 26. A transcription factor required for regulatory T cell development and function.