Lecture 10 - Vomiting Reflex, and Antiemetic Therepy

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Across
  1. 3. The stomach's ________ relax in third event in the vomiting reflex.
  2. 4. Preceding vomiting increased HR, respiration changes, and a change in ______ may be observed
  3. 5. ____________ prevent vomiting by acting on parasympathetic acetylcholine receptors.
  4. 6. Drowzee is a well known psychic pokemon. While little research has been compiled, it is likely that Drowzee manipulates the vestibular _________ receptors to put its opponents to sleep.
  5. 10. Dolasetron is an example of e 5HT3 receptor ________, and are thought to be an __________ for the 5HT3 CTZ and peripheral receptors.
  6. 11. ________ binds to the gut wall, enters the blood stream, and centrally stimulate vomiting.
  7. 13. The fifth event of vomiting is the relaxation of the ________-________ sphincter, which is stimulated to do so by increased pressure in the oesophagus.
  8. 18. Due to pallor change and other events preceding _________, you will have time to hold your friends hair out of the way before it gets too messy.
  9. 19. The _________ has the elegant name of the 'Vomiting Centre'.
  10. 20. After having a nightmare about Tony Abbott making another sexist remark in speedos, your vomiting reflex is triggered. Firstly, you inspire deeply while your _______ closes.
  11. 21. Metoclopramide, which is a _________ antagonist in the CTZ, is an antiemetic with side effects like depression, hyperactivity, and disorientation.
  12. 22. The second event in the vomiting reflex is the _______ of abdominal muscles and the diaphragm.
Down
  1. 1. Dopamine antagonist, Metoclopramide increases gastric _______ without affecting absorption and secretion. It does this by stimulating acetylcholine release, and increase sensitivity to acetylcholine in the visceral smooth muscle in the stomach.
  2. 2. If overused, these drugs cause atony, damage mucosa, and may lead to a predisposition for endotoxin penetration in the gut.
  3. 7. Phenothiazine is a _______ drug as it acts of many receptors, including dopamine receptors in the CTZ, medulla recepters, and muscular acetylocholine receptors.
  4. 8. Unlike vomiting, you wont see ____________ coming until the poorly digested and recently eaten food is all over your new carpet.
  5. 9. ___ (abb.), along with NK1 is a neurotransmitter associated with vomiting.
  6. 12. Vets may administer ________ _____ (2 words) to peripherally stimulate vomiting.
  7. 14. The newest class of effective antiemetics is the ___ (abb.) receptor antagonist.
  8. 15. The fourth event of the vomiting reflex is gastric content being forced into the ________ by strong abdominal and diaphragmatic contractions.
  9. 16. The final event of the vomiting reflex, and probably the least pleasant, is vomitus bursting through into your _______ cavity.
  10. 17. What can regulate gastric motility by: Strengthening oseophageal contractions; Increasing tone in the lower oesophageal sphincter; Increasing gastric atral contactions; Relaxing the pylorus; and by increasing SI contractions?
  11. 22. Blood-borne toxins act on the _____ (abb.) to stimulate the vomiting reflex.