Local Anesthetics Crossword Puzzle

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Across
  1. 2. Infected tissue is _______________
  2. 3. Abbreviation for CNS and cardiovascular effects when local anesthetics reach systemic circulation
  3. 6. Addition to local anesthetics that prolongs duration by causing vasoconstriction
  4. 8. Local anesthetic commonly used topically and associated with methemoglobinemia
  5. 9. Amide local anesthetic with intrinsic vasoconstriction
  6. 12. Ion channel blocked by local anesthetics to prevent nerve conduction
  7. 13. Class of local anesthetics metabolized in the liver
  8. 15. Local anesthetics become ________in infected tissues
  9. 17. Metabolite of prilocaine which causes methemoglobinemia
  10. 18. Local anesthetic with rapid onset due to high lipid solubility
  11. 19. Local anesthetic with the shortest duration and highest risk of allergy
  12. 20. Metabolite of ester type local anesthetics responsible for allergic reactions
  13. 21. Local anesthetic used topically for ENT procedures with NET blocking effects
  14. 22. Highly lipid soluble local anesthetic with bone penetration
Down
  1. 1. Local anesthetic with greatest potential of transient neurological symptoms
  2. 4. Amide local anesthetic which also has an ester
  3. 5. Syndrome caused by oxidation of hemoglobin associated with prilocaine and benzocaine
  4. 7. Form of the drug that can bind to and block the sodium channel
  5. 10. Patient population most affected by methemoglobinemia
  6. 11. Local anesthetic with highest cardiotoxicity risk
  7. 14. Type of local anesthetics metabolized by pseudocholinesterase
  8. 16. S-enantiomer of bupivacaine with less cardiotoxicity
  9. 19. Which sensation do local anesthetics inhibit first?