MCB*2050 Proteins

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Across
  1. 3. chloroplast equivalent of TOM
  2. 5. converts Ran-GTP to Ran-GDP
  3. 9. recognizes the signal sequence of nascent proteins targeted for the ER and binds their ribosome to stop translation
  4. 11. stimulates poly-ubiquitination of outer mitochondrial membrane, and marks it for degredation
  5. 12. one of three chaperone proteins of the ER lumen
  6. 14. promotes inner mitochondrial membrane fusion in a GTP dependent manner
  7. 16. integral membrane protein of the CGN which binds soluble proteins that are native to the ER lumen
  8. 17. works with Fis1 and MiD to recruit Drp1 to the outer mitochondrial membrane
  9. 18. binds GTP and integrates in the membrane of ER budding vesicles to assist in membrane curvature
  10. 19. binds proteins with an NES
  11. 20. undergoes GTP hydrolysis in order to cause fission of both inner and outer mitochondrial membranes
  12. 22. trims a glucose subunit from the oligosaccharide core on proteins in the ER lumen
  13. 25. integral ER protein also known as Sec61 (involved in co-translational translocation)
  14. 26. binds to either GGA adaptor proteins, or to PIP2 in order to induce membrane curvature in TGN/plasma membrane
  15. 29. translocase of the inner mitochondrial membrane which is responsible for import of proteins destined for the mitochondrial matrix
  16. 30. target membrane protein that interacts with vesicle membrane proteins in order to pull membrane together and mediate fusion
  17. 32. when BiP is no longer bound to its lumenal facing domain, it dimerizes to phosphorylate eLF2a to inhibit its translation factor function
  18. 33. works with Fis1 and Mff to recruit Drp1 to the outer mitochondrial membrane
  19. 35. marks proteins for degradation by proteasomes
  20. 36. partially degrades PINK1 in the intermembrane space of the mitochondria
  21. 38. binds proteins with an NLS
  22. 39. choroplast equivalent of TIM23
  23. 45. insures OPA1 mediated fusion of inner mitochondrial membranes only happens between 'different' membranes
  24. 47. recruited by Arf1-GTP and binds cytosolic domain of M6P receptor proteins, as well as recruits clatherin
  25. 48. responsible for tethering Golgi complex subunits to one another
  26. 50. one of three chaperone proteins of the ER lumen
  27. 51. recruited by Sar1-GTP, and assists in vesicle membrane curvature (does NOT associate with membrane cargo receptor proteins)
  28. 53. ensures cleaved, mature proteins in the stroma are properly folded
  29. 54. COPII component that causes the nascent vesicle to fully bud from the ER (higher number)
Down
  1. 1. GEF (guanine exchange factor) responsible for converting Ran-GDP to Ran-GTP
  2. 2. associates to the outer mitochondrial membrane (e.g. of mitochondria #2) and interacts with its counterpart to tether fusing mitochondria
  3. 4. adds a glucose to improperly folded proteins in the ER lumen (recognizes hydrophobic residues that are exposed in unfolded proteins)
  4. 5. responsible for the curvature of the endoreticulum membrane into cisternae and tubules
  5. 6. vesicle membrane protein that interacts with target membrane proteins in order to pull membranes together and mediate fusion
  6. 7. integral membrane protein of the TGN which binds soluble proteins destined for the endosome
  7. 8. catalyzes the reaction of uric acid to allantoin in most mammals
  8. 10. works with MiD and Mff to recruit Drp1 to the outer mitochondrial membrane
  9. 11. recruits Parkin when it accumulates on the outer mitochondrial membrane
  10. 13. converts cardiolipin to phosphotidic acid in order to facilitate fusion of closely associated outer mitochondrial membranes
  11. 15. binds GTP and associates with TGN membrane and is responsible for initial curvature (also responsible for the recruiting of GGA proteins)
  12. 21. one of three chaperon proteins of the ER lumen
  13. 23. associates to the outer mitochondrial membrane (e.g. of mitochondria #1) and interacts with its counterpart to tether fusing mitochondria
  14. 24. translocase of the outer mitochondrial membrane
  15. 27. cytosolic chaperone protein which brings nascent mitochondrial proteins to the outer mitochondrial membrane
  16. 28. assists in pulling nascent chloroplast targeted proteins into the stroma of the chloroplast
  17. 30. translocase of the inner mitochondrial membrane which is responsible for integration of proteins into the inner mitochondrial membrane
  18. 31. when no longer bound, its cytosolic subunit is released and acts as a transcription factor for ER molecular chaperones
  19. 34. associates with each other at the base of a new clathrin-coated vesicle, and uses GTP hydrolysis to release the clatherin coated vesicle
  20. 37. interacts with cytosolic filaments to enter the nucleus
  21. 40. cleaves the N-terminal presequence of proteins destined for mitochondrial import
  22. 41. mitochondrial matrix chaperone protein which assists in pulling nascent mitochondrial proteins into the mitochondrial matrix (also prevents back sliding)
  23. 42. family of membrane proteins that are responsible for vesicle targeting to recipient membrane
  24. 43. is in high concentration in the cytosol, and is converted to Ran-GDP in the nucleus
  25. 44. translation factor important in protein synthesis
  26. 46. is in high concentration in the nucleus, and binds exportin bound to a "cargo protein"
  27. 47. green fluorescence protein used in fluorescence microscopy
  28. 49. recruited by Sar1-GTP, and assists in vesicle membrane curvature as well as associating with membrane cargo receptor proteins
  29. 51. COPII component that causes the nascent vesicle to fully bud from the ER (lower number)
  30. 52. large complex formed by many proteins, involved in transport of proteins and RNAs to/from the nucleus