Across
- 6. presence within a cell of a uniform collection of mtDNA
- 7. Tendency of closely located genes to be inherited together
- 9. The presence of the same trait in both members of a pair of twins
- 12. Marker fused for genetic mapping
- 15. When a trait is phenotypically expressed only in homozygotes
- 16. Polymorphic drug metabolism gene
- 17. Series of cloned overlapping DNA fragments covering an entire chromosomic region
- 20. _______ bone disease
- 24. Sequence variant with a frequency in the population greater than 1%
- 26. Probability that a genotype manifests itself in a given phenotype
- 28. Type of DNA sequence variant
- 29. ______ number variation
- 30. Achondroplasia gene
- 31. Marker used in shotgun sequencing to aid sequence assembly
Down
- 1. Gain or loss of one type of chromosome
- 2. Klinefelter syndrome karyotype
- 3. Defective protein in Marfan Syndrome
- 4. Homozygosity for alleles identical by descent
- 5. Cloning vector used to sequence the human genome
- 8. 1000_________ Project
- 10. Project aiming to identify all of the functional elements in the human genome
- 11. NCBI’s sequence alignment tool
- 13. Series of alleles on a single chromosome that are in linkage and tend to be inherited together
- 14. _______ medicine, emerging approach for disease treatment and prevention that takes into account people’s unique characteristics
- 18. Parent-of-origin dependent gene expression
- 19. Marker used for genetic mapping
- 21. Presence of two or more populations of cells with different genotypes in one individual
- 22. The most abundant sequence variant in the human genome
- 23. Marker used in shotgun sequencing to aid sequence assembly
- 25. A measure of the likelihood of genetic linkage between loci
- 27. Method to analyse cell-free fetal DNA in the maternal circulataion