Methotrexate Toxicity

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Across
  1. 2. MTX was first discovered in what City?
  2. 5. Enzyme MTX inhibits
  3. 10. A term for inflammation of the mouth; risk of occurrence varies with dose of MTX.
  4. 12. Formulation of MTX that is most common
  5. 13. Monitor the patient's vital signs every ____hours for the first 24 hours.
  6. 15. Patients must have a MTX level ____ than 0.10 µM to be discharged.
  7. 16. MTX is an analog of what?
  8. 17. MTX is not selective for ____ cells, causing cytotoxic effects on healthy cells.
Down
  1. 1. What was MTX the first cure for?
  2. 3. In an overdose, cell death is seen more in organs with cells that divide rapidly, such as the GI tract and ____.
  3. 4. MTX is ____% protein bound.
  4. 6. Having No DNA or RNA synthesis leads to cytotoxic effects and ultimately cell____
  5. 7. Most commonly used antidote for MTX toxicity.
  6. 8. MTX concentration leads to increased MTX ____.
  7. 9. Administer____ if it was a recent overdose, the patient is not vomiting, and is able to maintain airway.
  8. 11. Consider gastric lavage if a patient presents within____ hour(s) of overdose and has taken a life-threatening amount.
  9. 14. What is needed for RNA and DNA synthesis that is inhibited by MTX