Across
- 1. ______strand is always produced in excess of the minus strand
- 4. Tissue _______:lack of receptor expression would protect a given tissue type from infection
- 6. RNA virus do not have a _______ phase.
- 8. DNA replication initiates at specific sites on template called ______.
- 10. T cells present ______ antigen to B cells in the germinal center
- 11. _______ immune system is activated within minutes to hours after infection
- 14. causes disease in the nervous system
- 16. enters the nervous system
- 17. this type of T cell is able to recognize antigen presented by MHC class 2.
- 21. a viral DNA _________ inhibitor example is Acyclovir
- 23. _______cells present antigens to T cells in the lymph nodes.
- 27. strength of a single virus binding to a single receptor is called:
- 31. HCV ________ paved the way for antiviral discovery.
- 32. an additional cell surface receptor that the virus interacts with
- 33. this must be produced by all viruses and recognized by cellular ribosomes in order to get proteins
- 36. RNA __________shield mRNA from RNA sensors
- 37. retroviruses can become _______ ie part of our DNA.
- 38. viral RNA sensors include RIG-I and ______.
- 41. mRNA ________ prevents RIG-I sensing of cellular RNA.
- 42. ______viruses can acquire their membranes from different sub-cellular locations.
- 43. +ssRNA virus that is in the Flaviviridae family
Down
- 1. _____infections are characterized as those in which the virus is not cleared but remain in specific cells of infected individuals
- 2. their expression in virus-infected cells is associated with tumor development
- 3. the genome of (+) RNA viruses
- 5. _________Factor: provides no other purpose than to provide a site for the virus to attach
- 7. these target one or more aspects of the viral life cycle in order to stop it.
- 9. genomic RNA is not ________, allowing for immediate translation
- 12. viral DNA replication always requires synthesis of at least ______ viral protein/s.
- 13. this is a RNA modifying enzyme that prevents self-RNA sensing
- 15. the first step in creating a vaccine immunogen against HIV that leads to a strong bnAB response is to id _________ with potent immunity during natural infection.
- 18. _______transport: needs barrier breach for infection
- 19. this is a classic antiviral ISG that blocks translation
- 20. ________Factor: required for viral internalization
- 22. _____infections are characterized by rapid onset of disease and resolution within days
- 24. all +strand viruses have genomic RNA that is _______.
- 25. viral assembly can be sequential or ________.
- 26. viruses ensure that nascent viral particles contain genomes with the use of ________signals.
- 28. some viral genomes have one ori, others up to _____.
- 29. in order for a viral infection to transform a cell, the cell must continue to __________.
- 30. DNA replication is always primer-dependent TRUE or FALSE
- 34. RNA is synthesized from an RNA template via ______ by RNA viruses
- 35. infects nervous system/nerve cells
- 39. combined strength of multiple bond interactions between a virion and cell receptors
- 40. DNA located here can lead to activation of the DNA sensing pathways (its a place DNA shouldn't normally be)