Module 2 Crossword 2

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Across
  1. 4. Over-expressed in RA, produces IL-1 and IL-6
  2. 5. disease Condition with acute symptoms including vomiting, abdominal pain, lethargy, diarrhoea
  3. 7. Growth factor with impaired immunosuppressive effects due to IL-15 in CD
  4. 8. disease Condition accompanied with HLA DQ2.2, 2.5, or DQ8
  5. 10. Decreased GFR/lower clearance rate high potassium
  6. 14. Caused by increased serum phosphate and low vitamin D production
  7. 16. Membrane protease used in alternative cleavage of spike protein in Coronavirus
  8. 18. Insulator that causes chromatin looping and extends insertional oncogenesis
  9. 19. Cardiomyopahty with unknown pathogenesis e.g. viral genetic alcohol
  10. 20. Both patients and staff administering treatment should not tell if patient is having treatment or placebo
  11. 21. inhibitor Diabetes treatment that binds to ATP-binding cleft of JAK kinase inhibits IFNy signalling prevents up-regulation of MHC I
Down
  1. 1. Arrythmia characterised by sinus node dysfunction or atrio-ventricular node block below 60bpm
  2. 2. JAK inhibitor used in BANDIT trial for type 1 diabetes
  3. 3. acidosis Loss of ability to synthesize ammonia and excrete hydrogen
  4. 5. Used in the mediated cleavage of spike protein in Coronavirus
  5. 6. Arrythmia characterised by over 100bpm
  6. 9. Transcribed from activation of t-bet promotes recruitment of infected cells and T cells to CNS induces astrocytes to release CLCX10
  7. 11. Cells used to observe the cytopathic effect of Coronavirus
  8. 12. Binds to inflammatory cytokines on surface of cells + free Abs in RA
  9. 13. endpoint Measure of effect of treatment but may not have guaranteed relationship
  10. 15. Amino acid with greater immunogenicity and resistance to digestive enzymes
  11. 17. Stops rapidly dividing cells from proliferating, but can also damage gut and oral mucosa