Module 2 Crossword 2

3. Stops rapidly dividing cells from proliferating, but can also damage gut and oral mucosa
6. Amino acid with greater immunogenicity and resistance to digestive enzymes
7. Membrane protease used in alternative cleavage of spike protein in Coronavirus
11. Arrythmia characterised by sinus node dysfunction or atrio-ventricular node block below 60bpm
13. Arrythmia characterised by over 100bpm
14. Cells used to observe the cytopathic effect of Coronavirus
15. Over-expressed in RA, produces IL-1 and IL-6
16. Transcribed from activation of t-bet promotes recruitment of infected cells and T cells to CNS induces astrocytes to release CLCX10
18. disease Condition accompanied with HLA DQ2.2, 2.5, or DQ8
19. endpoint Measure of effect of treatment but may not have guaranteed relationship
20. Cardiomyopahty with unknown pathogenesis e.g. viral genetic alcohol

1. Both patients and staff administering treatment should not tell if patient is having treatment or placebo
2. disease Condition with acute symptoms including vomiting, abdominal pain, lethargy, diarrhoea
4. Caused by increased serum phosphate and low vitamin D production
5. acidosis Loss of ability to synthesize ammonia and excrete hydrogen
7. Growth factor with impaired immunosuppressive effects due to IL-15 in CD
8. JAK inhibitor used in BANDIT trial for type 1 diabetes
9. Decreased GFR/lower clearance rate high potassium
10. Used in the mediated cleavage of spike protein in Coronavirus
12. Binds to inflammatory cytokines on surface of cells + free Abs in RA
17. inhibitor Diabetes treatment that binds to ATP-binding cleft of JAK kinase inhibits IFNy signalling prevents up-regulation of MHC I
18. Insulator that causes chromatin looping and extends insertional oncogenesis