Gene Therapy

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Across
  1. 2. A type of gene therapy where genes are changed in cells still in the body.
  2. 4. A type of gene therapy where cells are modified outside the body and then transplanted back in.
  3. 6. Disorders caused by the mutation in a single gene, often the target of gene therapy.
  4. 8. A method of introducing DNA into cells using an electric field.
  5. 10. Disorders caused by the combined action of more than one gene, more challenging for gene therapy.
  6. 11. A type of virus that can be used as a vector in gene therapy.
  7. 13. A genetic disorder that results in a weak immune system. It’s often a target for gene therapy
  8. 15. A type of retrovirus used as a vector in gene therapy.
  9. 16. A revolutionary gene-editing tool used in gene therapy.
  10. 18. The enzyme that acts like a pair of ‘molecular scissors’ in the CRISPR system.
  11. 19. The first person to undergo successful gene therapy.
  12. 20. This type of gene therapy targets cells that are not sperm or egg cells.
  13. 22. A method of introducing DNA into cells using a fine needle.
  14. 25. A type of engineered DNA-binding protein used in gene editing.
Down
  1. 1. A fat-based vector used in gene therapy.
  2. 3. The process of making precise and targeted modifications to the DNA of a cell.
  3. 5. These are used to deliver genetic material into cells in gene therapy.
  4. 7. A genetic disorder where blood does not clot normally, often treated with gene therapy.
  5. 9. A genetic disorder that has been a target for gene therapy.
  6. 12. A type of virus that can be used as a vector in gene therapy.
  7. 14. A type of treatment in which a patient’s T cells (a type of immune system cell) are changed in the lab so they will attack cancer cells.
  8. 17. A genetic disorder that Ashanti De Silva was treated for using gene therapy.
  9. 21. This controversial type of gene therapy involves changes to sperm or egg cells.
  10. 23. The gene that, when mutated, causes Cystic Fibrosis. It codes for a protein that regulates the movement of chloride and sodium ions across cell membranes.
  11. 24. An organ that can be affected by Cystic Fibrosis due to mutations in the CFTR gene.