nah

Edit Answers
12345678910111213141516171819202122232425262728293031323334353637383940414243444546474849505152535455565758596061626364656667686970717273747576777879808182838485868788899091929394
Across
  1. 3. Critical to get the final message out, bacteria don't bother doing this, as they don't have much to lose.
  2. 6. To release mediators from mast cell, an allergen must do this to the stores.
  3. 10. Several novel "Ozempic-Me Too" drugs were tested for their effects on somatostatin release. The one with the best safety profile released 65% of the somatostatin in comparison with the standard drug, but is still being considered for development even though it is a _____ agonist.
  4. 12. First done by Ed the separatist, but many use it to be very sequence specific.
  5. 15. Botox your face and see your wrinkles go—but I stay stuck in my bubble.
  6. 16. DEPENDENCE A newly discovered molecule shifts the concentration response of acetylcholine to the right but has no effect on a methylated derivative; this suggests that the molecule exhibits this (2 words, no hyphen).
  7. 17. An escort for an unfolded protein.
  8. 19. Opposes lead actors on a cellular stage.
  9. 20. KINASES Two words; no space: Call us just workhorses, but without us old cAMP stands little chances of being heard or felt.
  10. 23. Not a Dolittle technique but a Do Much way to use antibodies to find proteins.
  11. 25. When the rates of forward and backward chemical reactions are balanced.
  12. 26. A significant termination style.
  13. 28. A process whereby a simple aryl group is added to diverse spots on a histamine molecule—consequences are different though—it could become selectively active or neutralized.
  14. 29. Can provoke the release of mediators from sensitised cells.
  15. 30. A sort of probe that may make cells glow.
  16. 35. The phase where you add to the growing chain.
  17. 36. Linked with two others, but I am armed and ready to fire, just need a conformational change in that third intracellular loop to help me break away.
  18. 37. Octomeric protein with a flexible region that can be covalently modified.
  19. 38. A mobile stage for a dance of molecules?
  20. 40. The special amino acid made in the presence of selenium that is otherwise seen as a stop codon.
  21. 41. Sequence of nucleotide that often codes for protein.
  22. 43. This must happen to a stored messenger if it has to exert an effect.
  23. 45. After a ChAT with me, you could twitch a lot.
  24. 47. A critical step in the amplification cycle linking occupation of a beta-receptor in the hepatocyte to the production of glucose from glycogen.
  25. 48. Interruptions so to speak.
  26. 51. Changes in this can shift a dose-response on the y-axis.
  27. 52. I must do this to make the sticky things.
  28. 54. A generic term for a drug, mediator, messenger molecule that binds to a macromolecule to initiate an effect.
  29. 55. At the end of the chain linking reception and transduction.
  30. 58. Not a chocolate company at all but the male member of a team that did a crucial experiment in molecular biology.
  31. 59. You may call me open-minded or other-sighted since I permit some (maybe not all of the same kind) to stick to their own sites and even make them function better at times.
  32. 60. Between the reception and the response, falls not the shadow, but this process.
  33. 63. An enzyme in the removal business. Likes to keep things tight and tidy.
  34. 65. A critical cation for cellular signalling—enters through voltage gated channels at synaptic ends
  35. 67. Screaming guts, wetting pants? Perhaps a toxin has shut off this activity of one of the trimeric subunits of a trimeric protein (Gs).
  36. 68. OXIDASE A deficiency of this enzyme can cause histamine intolerance (two words).
  37. 74. CELL Two words; no space: Swollen I may be, but don't sting me — you will get red and itchy.
  38. 75. What a second messenger does to a received message.
  39. 76. An organic chemical containing nitrogen, not a place to harvest coal.
  40. 77. A mediator released by a cell that traverse the bloodstream to affect distant cells.
  41. 78. A dog may wag this, but it also is A critical signal for a transcript.
  42. 81. Antagonists to this receptor in different formulations can be useful for both ocular and cardiac diseases, though they may be lethal to those who rely on specific inhalants to ward off asthmatic attacks.
  43. 82. Kills histamine with (methyl) kindness.
  44. 83. Going to eat some dodgy fish? Keep me in your pocket.
  45. 86. A sole occupant of a methylation island.
  46. 88. Am utterly selfish, and useless since I reduce or shut down responses. When I get stuck—that's it. Others must wait till I get off unless there are so many that they jostle me around.
  47. 90. An important site for bonding before exiting the translating stage.
  48. 91. A product produced when the imidazole ring of a mast cell mediator is acted upon by a specific degrading enzyme.
  49. 92. Plays second fiddle as your heart burns and you reach for TUMS.
  50. 93. Would be brutal if done to political opponents, but an excellent strategy in protein synthesis.
  51. 94. A necklace of an mRNA thread and ribosome beads?
Down
  1. 1. Think of me as a truncated hydrocarbon—add me to specific spots on histamine and I can either make it more selective or nullify it effects.
  2. 2. An Un-fizzer of sorts. Maybe a Fizzer—depends how you look at it. A cytoplasmic amine generator.
  3. 4. Basal levels of cAMP rapidly decrease when you add this agonist to isolated cells in culture, you suspect it could be one of this sort.
  4. 5. Isolated cells that show baseline activity in the absence of any added agonist may have activity of this sort.
  5. 7. This must happen to a mast cell granule before it releases the stored package of mediators.
  6. 8. The agonist keeps calling, the receptor does not listen anymore—what has happened?
  7. 9. RNA pol II gets this job done.
  8. 10. I keep an important mediator in check; stopping me can be useful for old men who should know better.
  9. 11. A greasy sort of messenger, slips through cells with ease to get its message across.
  10. 13. Upstream of the initiator sequence, you will find this ‘box’ the site where TfIId binds.
  11. 14. This wiggly line may often be found in the ocean, but it’s not an oceanography term.
  12. 17. Repressed dinucleotide.
  13. 18. Bland I may be, but take off some of my fizziness and I can turn vicious.
  14. 21. A technique that uses fluorescent antibodies to localise receptors in tissue sections.
  15. 22. Chemists may label adenine as one such molecule.
  16. 24. Although sometimes leading or trailing, its importance is that it doesn't result in much and wouldn't be understood anyway.
  17. 25. These pictures reveal exquisite detail of cellular structures; magnets act as lenses (acronym).
  18. 27. A structure that stores histamine in mast cells.
  19. 31. A bacterial disease, where a toxin limits the GTPase activity of the activated alpha subunit of a G-protein.
  20. 32. When two different peptide chains come together.
  21. 33. The term used to describe amino acids used in making proteins.
  22. 34. Does a tau of 10 suggest the existence of this sort of receptor?
  23. 39. Not a blockbuster with shootouts and cowboys — a mundane technique to separate proteins.
  24. 42. Cellular FedEx.
  25. 44. Heritable changes that do not affect the template.
  26. 46. I can make you itch, scratch, give you heartburn, even make you sleepy. Ain't I wonderful?
  27. 49. Keep me cool, or you may suffer itchiness.
  28. 50. Complicated in hundreds of ways, absolutely necessary for things to properly begin.
  29. 53. Not just an item you may wear on your head, my activation leads to relaxation (acronym).
  30. 56. Guanine certainly not one.
  31. 57. Do not provoke this fat swollen cell, you will feel red.
  32. 58. An enzyme that adds a methyl group to the imidazole ring of histamine (acronym).
  33. 61. An aged man may be a paltry thing, but if you inhibit an isoform of this enzyme, they too can be erect, stand tall, and deliver.
  34. 62. When one’s destiny is to fold, this ...er...secret code marks the end.
  35. 64. A protein’s lament---I had to publish my thought in a brown book rather than a little “RED” one—just because I had one letter wrong.
  36. 66. After I am released I turn back to affect the same cell from which I am released. Am I a back-biting mediator?
  37. 69. SHIFTERS These shapeshifters ride work horses that link signal to response in cells.
  38. 70. A technique to sequence peptides starting from the N-terminal end.
  39. 71. An EC50 shift from 75μM to 15μM suggests an increase in?
  40. 72. An allosteric antagonist that produces a limited rightward shift in the concentration-response curve exhibits this phenomenon.
  41. 73. An undesirable trait in a member of a selection committee but a useful one in an agonist, perhaps.
  42. 79. Amino acid enriched in histone tails, adding an acetyl group is not such a positive thing.
  43. 80. A messenger of sorts; or just a neighbourhood gossip who talks to anyone who bothers to hear.
  44. 84. The ED50 of a novel compound releasing ghrelin from isolated cells is changed from 10 µM to 25 µM. A student labels it an orthosteric antagonist. The student is _____.
  45. 85. A lead actor in a cellular play; in the theatre though, may be called by a slightly different term.
  46. 87. This kind of enzyme not only limits the activity of a cAMP-dependent protein kinase but plays a crucial role in recycling desensitized receptors.
  47. 89. To quiet down transcription, a repressor may bind here.