Across
- 3. TCA H1-antagonist used for sleep maintenance
- 4. Short-acting barbiturate used for sedation
- 7. Rapid-elimination Z-drug hypnotic
- 10. Ionotropic receptor target of most sedative-hypnotics
- 12. S-enantiomer hypnotic with high α1 selectivity
- 15. Long-acting barbiturate with low lipophilicity
- 17. MT1/MT2 melatonin receptor agonist hypnotic
- 19. Benzodiazepine with long-lived active metabolites
- 20. Short-acting benzodiazepine hypnotic
- 22. Pineal hormone regulating circadian rhythm
- 24. OTC H1-antagonist sleep aid
Down
- 1. Sulfur-containing barbiturate anesthetic
- 2. Intermediate-acting barbiturate
- 5. Sedative class enhancing GABA A via BZR site
- 6. Benzodiazepine producing long-half-life metabolites
- 8. Sedative class binding barbiturate site on GABA A
- 9. H1-antagonist sedating antihistamine
- 11. Orexin receptor antagonist for insomnia
- 13. Benzodiazepine with less active metabolites
- 14. α2δ calcium-channel ligand increasing GABA synthesis
- 16. Intermediate-acting barbiturate
- 18. Wake-promoting neuropeptide blocked by suvorexant
- 21. Z-drug selective for α1-GABA A subtype
- 23. Short-acting barbiturate with high lipophilicity