Across
- 3. Orexin antagonist with ~18-hr half-life
- 5. Low-dose TCA used for sleep maintenance
- 7. Sleep onset time reduced by hypnotic
- 9. NBzRA with unpleasant taste adverse effect
- 11. OTC H1 antagonist sleep aid
- 13. Herbal product with possible GABAergic activity
- 15. Subjective complaint of poor sleep despite adequate opportunity
- 17. Nonbenzodiazepine benzodiazepine receptor agonist class
- 19. Short-acting benzodiazepine for sleep onset
- 20. Sedating antidepressant causing weight gain
- 21. Sleep stage associated with dreaming
- 22. Sedating antidepressant with rare priapism risk
Down
- 1. Dual orexin receptor antagonist hypnotic
- 2. Ultrashort-acting Z-drug for sleep onset
- 4. OTC antihistamine hypnotic
- 6. NBzRA α1-selective GABA A agonist hypnotic
- 8. First-line nonpharmacologic treatment for chronic insomnia
- 10. Receptor targeted by benzos and Z-drugs
- 12. Orexin antagonist with ~8-hr half-life
- 14. Pineal hormone regulating circadian rhythm
- 16. Deep slow-wave restorative sleep stage
- 18. MT1/MT2 agonist hypnotic not controlled substance
- 19. Intermediate-acting benzodiazepine for sleep maintenance
- 23. Wake-promoting neuropeptide blocked by DORAs