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Across
  1. 4. Syntax hole?
  2. 5. dome-icile
  3. 7. A place for skeletons
  4. 8. Villainous hideout
  5. 10. Seedy center
  6. 12. Primary candidate
  7. 13. Dress for the weather?
  8. 14. Bossy suit
  9. 18. dry
  10. 19. shade
  11. 20. Bar final
  12. 21. Dietary unit
  13. 24. Native big wig
  14. 27. Lowest point
  15. 29. Nickname of Hemingway
  16. 30. An element of change
  17. 31. major
  18. 33. Lost king?
  19. 35. For when you are steaming
  20. 37. Dog transport?
  21. 39. A smarting blow
  22. 41. Pretty, as an animal
  23. 43. What this puzzle lacks
  24. 44. A set for mothers
  25. 45. Smell
Down
  1. 1. Busy
  2. 2. Meaty dessert?
  3. 3. Jewelers monocle
  4. 6. Rug adjective
  5. 9. state Iowa, for one
  6. 11. After-dinner drink
  7. 15. Relating to Mars, Earth, etc.
  8. 16. Beer
  9. 17. Feeling a bit ______
  10. 22. Misery acquaints a man with strange ______
  11. 23. Down opposite
  12. 25. Circuitous
  13. 26. Arises from the ashes
  14. 28. Keep calm and _______
  15. 32. Vino tinto
  16. 34. Beehive
  17. 36. Highest point
  18. 38. Sandwich, e.g.
  19. 40. Cheesy crust
  20. 42. Follows a bump
  21. 43. Cooked bread
  22. 45. Marine feed