Across
- 2. First major Isaac expansion (abbr.)
- 5. The middle child.
- 7. Arduous Isaac run.
- 10. "Loki had a medkit!" game.
- 13. Never before seen enemy.
- 18. Last item needed for Real Platinum God in 2015 (2 words)
- 20. NL's native province.
- 24. Nick's alter-ego.
- 25. "Check the Wire" co-host.
- 27. Certified developer, or a team of 4.
- 28. Isaac artifacting culprit.
- 31. Former South Korean residence.
- 32. Former Monday show staple.
- 35. Scooters alternative.
- 37. NL's preferred martial art.
- 38. The eldest child.
- 39. Amusingly unconventional, like taking soy milk.
- 40. Skilled tetris player.
Down
- 1. Bo, Canucks center
- 3. Might be blamed for an Isaac bug.
- 4. Amazon hosted mobile games tournament (abbr.)
- 5. Many an RPG's protagonist.
- 6. Old NLSS insult.
- 8. Agree reluctantly.
- 9. Vancouver's timezone (abbr.)
- 11. M of MALF
- 12. Viral twitter Kiwi.
- 14. Deceptive rock.
- 15. Not guaranteed, despite good items (2 words)
- 16. College field of study.
- 17. Former subscriber demonym (2 words)
- 19. Toasted and Burnt predecessor.
- 21. 1/2 of the Dad Squad. (He'd like his beret back!)
- 22. Let's Play - The Binding of Isaac - Episode 1 ___
- 23. Debut series on the channel.
- 26. "Time to go!" skit show (abbr.)
- 29. Titled chess tutor.
- 30. "That's B Ranch ___"
- 33. Alternative to Mounting your Friends.
- 34. The brain to NL's hand
- 36. Dehydrated run saver (2 words)