OCAT 5

Edit Answers
123456789101112131415161718192021
Across
  1. 3. Pharmacologist's spa: warm, oxygenated salt solution holding a tissue strip tied to a force transducer. (9 letters)
  2. 4. Named for its inventor, not a compass point: DNA fragments transferred to a membrane and probed. (8 letters)
  3. 7. Erwin, German who shared the 1991 Nobel with Sakmann for single ion channel work. (5 letters)
  4. 10. Rightward parallel shift of the agonist curve with an unchanged maximum: more agonist can climb over it like a hill. (12 letters)
  5. 11. Rarest circulating granulocytes, with blue-staining granules full of histamine. (9 letters)
  6. 13. The P site holds the tRNA carrying the growing chain; the transferase that forms the peptide bond is named for this. (8 letters)
  7. 14. Chemist whose adsorption model of molecules on a surface inspired how drugs bind finite receptor sites. (8 letters)
  8. 17. Repetitive TTAGGG caps on the ends of chromosomes, like the aglets on shoelaces that stop fraying. (8 letters)
  9. 18. Five-letter plate assay that sounds like a girl's name. (5 letters)
  10. 20. Swedish forename of a UN secretary-general; also the lipid that recruits PKC to the membrane. (3 letters)
  11. 21. Membranes merge and the contents pour out: the final stage of exocytosis. (6 letters)
Down
  1. 1. Denature, anneal, extend, repeat: three letters for billions of copies. (3 letters)
  2. 2. DAO can't keep up, so flushing and headaches follow red wine and aged cheese: not an allergy, but this. (11 letters)
  3. 5. Earl who discovered cAMP, winning the 1971 Nobel. (10 letters)
  4. 6. Before the first bond is made, general TFs and RNA pol II assemble at the promoter in this complex. (13 letters)
  5. 8. Literally 'above genetics': heritable changes in expression without changes in DNA sequence. (11 letters)
  6. 9. Lipid second messenger that stays in the membrane after PIP2 cleavage and activates PKC. (14 letters)
  7. 12. Raymond who split adrenoceptors into alpha and beta in 1948. (8 letters)
  8. 15. Testable 'if...then' guess that an experiment is designed to evaluate. (10 letters)
  9. 16. George de ___, Hungarian pioneer of radioactive tracers and 1943 Nobel winner. (6 letters)
  10. 19. Fast, targeted signalling across a tiny cleft between a neuron and its partner cell. (8 letters)