One-Compartment Model

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Across
  1. 2. Does VD correlate to a “real” or physiological compartment?
  2. 3. ____________ interactions can change the VD
  3. 5. Least Number of plasma samples required to calculate k or t ½
  4. 9. Rapid IV administration of a single dose of drug
  5. 11. First order elimination equations utilize the _______ log of the concentration in the plasma
  6. 12. VD is the ____ of the compartment required to account for the total quantity of drug in the body
  7. 14. For first order reactions, t ½ is _________
  8. 17. Units of this rate constant are h-1 (SPELL OUT)
  9. 18. The concentration of the drug is taken from a sample of the patient’s _________
  10. 19. k = 0.693 / (SPELL OUT)
  11. 21. DB0 is the amount of drug in the body at time = (SPELL)
  12. 22. If VD is increased, you need to ________ the dose to achieve a desired plasma concentration
Down
  1. 1. Parameter that relates the measured concentration of the drug to the total amount of drug in the body
  2. 4. ____ increases the VD of a drug (one word)
  3. 6. ________ binding can lead to a decrease in VD (two words, no space)
  4. 7. Slope = -k in this order of elimination
  5. 8. A one-compartment model has _______ distribution
  6. 10. If you cannot change the dose of the drug but you need to raise the concentration, you can change the __________ of administration
  7. 13. ________ = ln Cp0
  8. 15. VD > 10,000 means the drug lies mostly in the ______
  9. 16. The total drug in the body (DB) is typically measured in what?
  10. 20. VD represents the concentration in the body being the _____ as the concentration in the plasma